Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 16/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 7/20 | 1.00 |
| ▸ | MEN1 | O00255 | 6/20 | 1.00 |
| ▸ | HPGD | P15428 | 5/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | GLA | P06280 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.79 |
| ▸ | GAA | P10253 | 5/20 | 0.77 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.76 |
| ▸ | TP53 | P04637 | 1/20 | 0.68 |
| ▸ | CASP1 | P29466 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | USP2 | O75604 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | MST1R | Q04912 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4428402 | 0.78 | KDM4E (0.63) | MAPTALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL644092 | 0.78 | KDM4E (0.63) | MAPTALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL16383912 | 0.76 | MAPT (0.71) | MAPTALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL5646247 | 0.75 | MAPT (0.82) | MAPTALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL13166883 | 0.74 | MST1R (1.00) | MAPTALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL26459360 | 0.73 | MAPT (1.00) | MAPTALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL2007035 | 0.73 | MEN1 (0.76) | MAPTALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL4420851 | 0.72 | ALDH1A1 (0.74) | MAPTALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL3129403 | 0.72 | ALDH1A1 (0.65) | MAPTALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL4425365 | 0.72 | ALDH1A1 (0.74) | MAPTALDH1A1KDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040235849-A1 | Tetrahydroquinoxalines acting as bradykinin antagonists | BAYER HEALTHCARE AG (DE) | 2004-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040235849-A1 | Tetrahydroquinoxalines acting as bradykinin antagonists | BDKRB2, BDKRB1, LTB4R2 | MAPT 3174/4885ALDH1A1 4292/4885KDM4E 3548/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.