Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPM1B | O75688 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17756059 | 1.00 | PPM1B (0.41) | PPM1BPTPN1PPP1CCMAPTALDH1A1 | |
| SCHEMBL10841947 | 0.81 | MAPT (0.37) | PPM1BPTPN1PPP1CCMAPTALDH1A1 | |
| SCHEMBL12457799 | 0.81 | MAPT (0.37) | MAPTALDH1A1 | |
| SCHEMBL17929007 | 0.81 | MAPT (0.37) | PPM1BPTPN1MAPTALDH1A1 | |
| SCHEMBL14376624 | 0.81 | MAPT (0.37) | MAPTALDH1A1 | |
| SCHEMBL20706445 | 0.80 | MAPT (0.36) | MAPTALDH1A1 | |
| SCHEMBL17756060 | 0.80 | KDM4E (0.40) | MAPTALDH1A1 | |
| SCHEMBL13110289 | 0.80 | PPM1B (0.37) | PPM1BPTPN1PPP1CCMAPTALDH1A1 | |
| SCHEMBL7826374 | 0.79 | GABRR1 (0.46) | MAPTALDH1A1 | |
| SCHEMBL19080639 | 0.79 | GABRR1 (0.46) | MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120142752-A1 | HIV PROTEASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142752-A1 | HIV PROTEASE INHIBITORS | SERPINB1, PRSS1, SERPINB6 | PPM1B 1660/4885PTPN1 2778/4885PPP1CC 3168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.