Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX12 | P18054 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 8/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TYR | P14679 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL329883 | 0.91 | ALOX12 (0.47) | ALOX12ALOX15CYP19A1CYP3A4KCNH2 | |
| SCHEMBL12055312 | 0.89 | ALOX12 (0.44) | ALOX12ALOX15CYP19A1CYP3A4KCNH2 | |
| SCHEMBL154220 | 0.87 | ALOX12 (0.42) | ALOX12ALOX15CYP19A1CYP3A4KCNH2 | |
| SCHEMBL329909 | 0.85 | NR3C1 (0.48) | ALOX12ALOX15CYP19A1CYP3A4KCNH2 | |
| SCHEMBL131535 | 0.83 | ALOX12 (0.42) | ALOX12ALOX15CYP19A1CYP3A4KCNH2 | |
| SCHEMBL242978 | 0.79 | CYP19A1 (0.61) | ALOX12ALOX15CYP19A1CYP3A4KCNH2 | |
| SCHEMBL2604717 | 0.79 | CYP19A1 (0.64) | ALOX12ALOX15CYP19A1CYP3A4KCNH2 | |
| SCHEMBL3957591 | 0.76 | ALOX12 (0.53) | ALOX12ALOX15CYP19A1CYP3A4KCNH2 | |
| SCHEMBL24103982 | 0.75 | PREP (0.41) | ALOX12ALOX15CYP19A1KCNH2TRPV1 | |
| SCHEMBL2071244 | 0.75 | ALOX12 (0.64) | ALOX12ALOX15CYP19A1CYP3A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2407462-A1 | Substituted chroman derivatives, medicaments and use in therapy | Marshall Edwards, Inc. (US) | 2012-01-18 | — | — | EP | disclosed |
| US-8084628-B2 | Substituted chroman derivatives, medicaments and use in therapy | MARSHALL EDWARDS, INC. (US) | 2011-12-27 | — | — | US | disclosed |
| EP-1794141-B1 | SUBSTITUTED CHROMAN DERIVATIVES, MEDICAMENTS AND USE IN THERAPY | MARSHALL EDWARDS INC (US) | 2011-11-09 | — | — | EP | disclosed |
| US-7601855-B2 | anticancer agents; chemotherapeutic selective agents | NOVOGEN RESEARCH PTY LTD (AU) | 2009-10-13 | — | — | US | disclosed |
| US-7601855-B2 | anticancer agents; chemotherapeutic selective agents | NOVOGEN RESEARCH PTY LTD (AU) | 2009-10-13 | — | — | US | disclosed |