Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.78 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.78 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.78 |
| ▸ | TP53 | P04637 | 5/20 | 0.72 |
| ▸ | LMNA | P02545 | 3/20 | 0.72 |
| ▸ | THRB | P10828 | 2/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | PKM | P14618 | 6/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25010388 | 0.81 | TP53 (0.71) | MAPTTP53LMNATHRBGAA | |
| SCHEMBL25010896 | 0.77 | PKM (0.79) | TP53LMNATHRBPKM | |
| SCHEMBL25009227 | 0.76 | PKM (0.83) | TP53LMNATHRBPKM | |
| SCHEMBL25009096 | 0.75 | PKM (0.70) | MAPTTP53LMNATHRBPKM | |
| SCHEMBL25009095 | 0.74 | PKM (0.80) | TP53LMNATHRBPKM | |
| SCHEMBL25010953 | 0.73 | PKM (1.00) | MAPTTP53LMNATHRBPKM | |
| SCHEMBL18184511 | 0.73 | TP53 (0.64) | MAPTL3MBTL1TP53LMNATHRB | |
| SCHEMBL25010014 | 0.73 | PKM (1.00) | TP53LMNAPKMMEN1KMT2A | |
| SCHEMBL18184455 | 0.73 | TP53 (0.67) | MAPTTP53LMNATHRBGAA | |
| SCHEMBL2588150 | 0.73 | PKM (1.00) | TP53LMNATHRBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012016133-A2 | ROS1 KINASE INHIBITORS FOR THE TREATMENT OF GLIOBLASTOMA AND OTHER P53-DEFICIENT CANCERS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-02-02 | — | — | WO | disclosed |