Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 6/20 | 0.64 |
| ▸ | THRB | P10828 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | PKM | P14618 | 8/20 | 0.60 |
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18184455 | 0.85 | TP53 (0.67) | TP53THRBMAPTMEN1KMT2A | |
| SCHEMBL16032121 | 0.84 | TP53 (0.66) | TP53THRBMAPTMEN1KMT2A | |
| SCHEMBL25010388 | 0.84 | TP53 (0.71) | TP53THRBMAPTMEN1KMT2A | |
| SCHEMBL24809087 | 0.83 | TP53 (0.64) | TP53THRBMAPTMEN1KMT2A | |
| SCHEMBL20364522 | 0.82 | TP53 (0.63) | TP53THRBMAPTMEN1KMT2A | |
| SCHEMBL2953764 | 0.80 | MMP12 (0.64) | TP53THRBMAPTMEN1KMT2A | |
| SCHEMBL20703688 | 0.78 | ALDH1A1 (0.60) | TP53THRBMAPTMEN1KMT2A | |
| SCHEMBL25009096 | 0.78 | PKM (0.70) | TP53THRBMAPTPKMLMNA | |
| SCHEMBL25009515 | 0.77 | PKM (0.80) | TP53THRBMAPTPKMLMNA | |
| SCHEMBL25009511 | 0.77 | MEN1 (1.00) | TP53THRBMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016172631-A2 | SUBSTRATE SELECTIVE INHIBITORS OF INSULIN-DEGRADING ENZYME (IDE) AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-10-27 | — | — | WO | disclosed |