Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 18/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 18/20 | 0.55 |
| ▸ | NPC1 | O15118 | 6/20 | 0.55 |
| ▸ | MAPT | P10636 | 8/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | HPGD | P15428 | 5/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.55 |
| ▸ | THRB | P10828 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.55 |
| ▸ | USP2 | O75604 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.55 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 8/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.52 |
| ▸ | HPN | P05981 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30570964 | 0.76 | CREBBP (0.50) | MEN1KMT2ANPC1MAPTALOX15 | |
| SCHEMBL6587899 | 0.76 | CREBBP (0.50) | MEN1KMT2ANPC1MAPTALOX15 | |
| SCHEMBL13330038 | 0.76 | MEN1 (0.55) | MEN1KMT2ANPC1MAPTALDH1A1 | |
| SCHEMBL15040890 | 0.76 | MEN1 (0.55) | MEN1KMT2ANPC1MAPTALDH1A1 | |
| SCHEMBL19262253 | 0.76 | MEN1 (0.50) | MEN1KMT2ANPC1MAPTALDH1A1 | |
| SCHEMBL13035675 | 0.74 | MEN1 (0.84) | MEN1KMT2ANPC1MAPTALDH1A1 | |
| SCHEMBL11509136 | 0.73 | MEN1 (0.49) | MEN1KMT2ANPC1MAPTALDH1A1 | |
| SCHEMBL4160714 | 0.71 | MEN1 (0.70) | MEN1KMT2ANPC1MAPTALDH1A1 | |
| SCHEMBL13856670 | 0.71 | MEN1 (1.00) | MEN1KMT2ANPC1MAPTALDH1A1 | |
| SCHEMBL13035685 | 0.71 | MEN1 (1.00) | MEN1KMT2ANPC1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012016133-A2 | ROS1 KINASE INHIBITORS FOR THE TREATMENT OF GLIOBLASTOMA AND OTHER P53-DEFICIENT CANCERS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-02-02 | — | — | WO | disclosed |