Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BIRC2 | Q13490 | 6/20 | 0.45 |
| ▸ | XIAP | P98170 | 6/20 | 0.45 |
| ▸ | BIRC3 | Q13489 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | CASP9 | P55211 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | PREP | P48147 | 1/20 | 0.36 |
| ▸ | FAP | Q12884 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18754863 | 1.00 | BIRC2 (0.45) | BIRC2XIAPBIRC3CYP3A4CYP2C9 | |
| SCHEMBL25638567 | 0.88 | HTT (0.39) | BIRC2XIAPBIRC3DPP4PREP | |
| SCHEMBL13073730 | 0.86 | BIRC2 (0.38) | BIRC2XIAPBIRC3CYP3A4CYP2C9 | |
| SCHEMBL10080104 | 0.85 | DPP4 (0.41) | DPP4PREPFAPELANE | |
| SCHEMBL3722484 | 0.85 | BIRC2 (0.50) | BIRC2XIAPBIRC3CYP3A4CYP2C9 | |
| SCHEMBL12747459 | 0.84 | DPP4 (0.41) | DPP4PREPFAPELANE | |
| SCHEMBL22794202 | 0.84 | DPP4 (0.41) | DPP4PREPFAPELANE | |
| SCHEMBL25917717 | 0.84 | DPP4 (0.41) | DPP4PREPFAPELANE | |
| SCHEMBL9965794 | 0.84 | DPP4 (0.49) | BIRC2XIAPDPP4 | |
| SCHEMBL14050770 | 0.84 | BIRC2 (0.54) | BIRC2XIAPBIRC3CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120195915-A1 | IAP BIR domain binding compounds | PHARMASCIENCE INC. (CA) | 2012-08-02 | — | — | US | disclosed |
| US-8163792-B2 | IAP BIR domain binding compounds | PHARMASCIENCE INC. (CA) | 2012-04-24 | — | — | US | disclosed |
| US-20100292269-A1 | BIR DOMAIN BINDING COMPOUNDS | AEGERA THERAPEUTICS, INC. (CA) | 2010-11-18 | — | — | US | disclosed |
| US-20090192140-A1 | IAP BIR DOMAIN BINDING COMPOUNDS | AEGERA THERAPEUTICS INC. (CA) | 2009-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292269-A1 | BIR DOMAIN BINDING COMPOUNDS | BIRC5, BIRC3, BIRC2 | BIRC2 3/4885XIAP 6/4885BIRC3 2/4885 |
| US-20120195915-A1 | IAP BIR domain binding compounds | BIRC5, BIRC2, BIRC3 | BIRC2 2/4885XIAP 6/4885BIRC3 3/4885 |
| US-20090192140-A1 | IAP BIR DOMAIN BINDING COMPOUNDS | BIRC5, BIRC2, BIRC3 | BIRC2 2/4885XIAP 6/4885BIRC3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.