Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.72 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.72 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.72 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.72 |
| ▸ | HPGD | P15428 | 1/20 | 0.72 |
| ▸ | TCF4 | P15884 | 1/20 | 0.72 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.72 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.72 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.72 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.72 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29392404 | 0.84 | ALDH1A1 (1.00) | ALDH1A1PSMB1PSMB5PSMB2CYP1A2 | |
| SCHEMBL2243581 | 0.84 | ALDH1A1 (1.00) | ALDH1A1PSMB1PSMB5PSMB2CYP1A2 | |
| SCHEMBL10058113 | 0.80 | KDM4E (0.52) | ALDH1A1PSMB1PSMB5PSMB2CYP1A2 | |
| SCHEMBL2244851 | 0.79 | ALDH1A1 (0.80) | ALDH1A1PSMB1PSMB5PSMB2CYP1A2 | |
| SCHEMBL2243856 | 0.79 | ALDH1A1 (0.80) | ALDH1A1PSMB1PSMB5PSMB2CYP1A2 | |
| SCHEMBL7968228 | 0.77 | ALDH1A1 (0.77) | ALDH1A1PSMB1PSMB5PSMB2CYP1A2 | |
| SCHEMBL2241689 | 0.77 | PSMB5 (0.76) | ALDH1A1PSMB1PSMB5PSMB2CYP1A2 | |
| SCHEMBL2243805 | 0.77 | PSMB5 (0.76) | ALDH1A1PSMB1PSMB5PSMB2CYP1A2 | |
| SCHEMBL8067727 | 0.75 | KDM4E (0.66) | ALDH1A1HSD17B10KDM4ELMNASMN1; SMN2 | |
| SCHEMBL2242287 | 0.74 | PSMB1 (0.72) | ALDH1A1PSMB1PSMB5PSMB2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120142917-A1 | PROTEASOME INHIBITORS HAVING CHYMOTRYPSIN-LIKE ACTIVITY | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142917-A1 | PROTEASOME INHIBITORS HAVING CHYMOTRYPSIN-LIKE ACTIVITY | PSMB4, PSME4, PSMB1 | ALDH1A1 3758/4885PSMB1 3/4885PSMB5 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.