Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX12 | P18054 | 13/20 | 0.72 |
| ▸ | L3MBTL1 | Q9Y468 | 10/20 | 0.72 |
| ▸ | MEN1 | O00255 | 9/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.72 |
| ▸ | LMNA | P02545 | 8/20 | 0.72 |
| ▸ | HTT | P42858 | 7/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.72 |
| ▸ | MAPT | P10636 | 6/20 | 0.72 |
| ▸ | BLM | P54132 | 1/20 | 0.72 |
| ▸ | NPC1 | O15118 | 7/20 | 0.61 |
| ▸ | RAB9A | P51151 | 6/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 8/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | HSP90AA1 | P07900 | 7/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.57 |
| ▸ | MMP2 | P08253 | 2/20 | 0.57 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10078791 | 0.88 | ALOX12 (0.76) | ALOX12L3MBTL1MEN1KMT2ALMNA | |
| SCHEMBL608473 | 0.86 | ALOX12 (0.81) | ALOX12L3MBTL1MEN1KMT2ALMNA | |
| SCHEMBL1541934 | 0.84 | ALOX12 (1.00) | ALOX12L3MBTL1MEN1KMT2ALMNA | |
| SCHEMBL2598269 | 0.76 | ALOX12 (1.00) | ALOX12L3MBTL1MEN1KMT2ALMNA | |
| SCHEMBL607837 | 0.76 | ALOX12 (1.00) | ALOX12L3MBTL1MEN1KMT2ALMNA | |
| SCHEMBL2598260 | 0.76 | ALOX12 (1.00) | ALOX12L3MBTL1MEN1KMT2ALMNA | |
| SCHEMBL29509652 | 0.76 | ALOX12 (1.00) | ALOX12L3MBTL1MEN1KMT2ALMNA | |
| SCHEMBL608048 | 0.75 | KDM4E (1.00) | ALOX12L3MBTL1MEN1KMT2ALMNA | |
| SCHEMBL2598274 | 0.74 | ALOX12 (1.00) | ALOX12L3MBTL1MEN1KMT2ALMNA | |
| SCHEMBL609894 | 0.74 | ALOX12 (1.00) | ALOX12L3MBTL1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012012653-A1 | COMBINATION THERAPY WITH MDM2 AND EFGR INHIBITORS | ERRICO JOSEPH P (US) | 2012-01-26 | — | — | WO | disclosed |