Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX12 | P18054 | 14/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 9/20 | 1.00 |
| ▸ | NPC1 | O15118 | 9/20 | 1.00 |
| ▸ | RAB9A | P51151 | 8/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.72 |
| ▸ | MEN1 | O00255 | 6/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.72 |
| ▸ | LMNA | P02545 | 5/20 | 0.72 |
| ▸ | MAPT | P10636 | 4/20 | 0.72 |
| ▸ | HTT | P42858 | 4/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.72 |
| ▸ | GAA | P10253 | 1/20 | 0.72 |
| ▸ | HSP90AA1 | P07900 | 8/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.58 |
| ▸ | MMP2 | P08253 | 2/20 | 0.58 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2598269 | 1.00 | ALOX12 (1.00) | ALOX12L3MBTL1NPC1RAB9AKDM4E | |
| SCHEMBL2598274 | 0.89 | ALOX12 (1.00) | ALOX12L3MBTL1NPC1RAB9AKDM4E | |
| SCHEMBL2598260 | 0.88 | ALOX12 (1.00) | ALOX12L3MBTL1NPC1RAB9AKDM4E | |
| SCHEMBL607837 | 0.88 | ALOX12 (1.00) | ALOX12L3MBTL1NPC1RAB9AKDM4E | |
| SCHEMBL608048 | 0.84 | KDM4E (1.00) | ALOX12L3MBTL1NPC1RAB9AKDM4E | |
| SCHEMBL2598255 | 0.83 | ALOX12 (1.00) | ALOX12L3MBTL1NPC1RAB9AKDM4E | |
| SCHEMBL4044485 | 0.83 | RAB9A (0.78) | ALOX12L3MBTL1NPC1RAB9AKDM4E | |
| SCHEMBL608473 | 0.78 | ALOX12 (0.81) | ALOX12L3MBTL1NPC1RAB9AKDM4E | |
| SCHEMBL609894 | 0.77 | ALOX12 (1.00) | ALOX12L3MBTL1NPC1RAB9AKDM4E | |
| SCHEMBL10079880 | 0.76 | ALOX12 (0.72) | ALOX12L3MBTL1NPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3054936-B1 | 4-((2-HYDROXY-3-METHOXYBENZYL)AMINO) BENZENESULFONAMIDE DERIVATIVES AS 12-LIPOXYGENASE INHIBITORS | EASTERN VIRGINIA MEDICAL SCHOOL (US) | 2023-10-18 | — | — | EP | disclosed |
| US-11274077-B2 | 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase | EASTERN VIRGINIA MEDICAL SCHOOL (US) | 2022-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11274077-B2 | 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase | ALOX12, ALOX15, ALOX15B | ALOX12 1/4885L3MBTL1 491/4885NPC1 4611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.