SCHEMBL1008026

SCHEMBL1008026

COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OC(C)C1CCNCC1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDR P35968 16/20 0.72
EGFR P00533 13/20 0.72
FLT1 P17948 13/20 0.72
FGFR1 P11362 12/20 0.72
FLT4 P35916 11/20 0.72
RET P07949 2/20 0.70
KIF5B P33176 2/20 0.70
EPHA2 P29317 3/20 0.62
PDGFRB P09619 2/20 0.61
TEK Q02763 2/20 0.61
EPHB2 P29323 2/20 0.61
EPHB4 P54760 2/20 0.61
BMPR1B O00238 1/20 0.61
PLK4 O00444 1/20 0.61
CIT O14578 1/20 0.61
GAK O14976 1/20 0.61
EPHB6 O15197 1/20 0.61
RIPK2 O43353 1/20 0.61
ROCK2 O75116 1/20 0.61
STK10 O94804 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL27735443 0.99 KDR (0.71) KDREGFRFLT1FGFR1FLT4
Hydrochloric Acid SCHEMBL6454560 0.99 KDR (0.71) KDREGFRFLT1FGFR1FLT4
Trifluoroacetic Acid SCHEMBL6902285 0.93 KDR (0.65) KDREGFRFLT1FGFR1FLT4
SCHEMBL2200924 0.91 KDR (0.74) KDREGFRFLT1FGFR1FLT4
SCHEMBL2203010 0.90 FLT1 (0.73) KDREGFRFLT1FGFR1FLT4
Hydrochloric Acid SCHEMBL7477739 0.90 FLT1 (0.75) KDREGFRFLT1FGFR1FLT4
SCHEMBL2200083 0.89 EGFR (0.73) KDREGFRFLT1FGFR1FLT4
SCHEMBL5506368 0.86 EGFR (0.56) KDREGFRFLT1FGFR1FLT4
SCHEMBL4604150 0.85 KDR (0.64) KDREGFRFLT1FGFR1FLT4
SCHEMBL1612820 0.85 KDR (0.84) KDREGFRFLT1FGFR1FLT4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 256 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4110796-A1 CHIMERIC FUSIONS BETWEEN C4-BINDING PROTEIN C-TERMINAL SEGMENT AND ANGIOPOIETIN-1 FIBRINOGEN-LIKE DOMAIN AS ANGIOPOIETIN MIMETICS AND TIE2 AGONISTS TO TREAT VASCULAR DISEASES Northwestern University (US) 2023-01-04 EP claimed
EP-1620104-A1 THERAPEUTIC AGENTS COMPRISING AN ANTI-ANGIOGENIC AGENT IN COMBINATION WITH AN SRC-INHIBITOR AND THEIR THERAPEUTIC USE Astrazeneca AB (SE) 2006-02-01 EP claimed
EP-1592423-A2 COMBINATION THERAPY OF ZD6474 WITH 5-FU AND/OR CPT-11 Astrazeneca AB (SE) 2005-11-09 EP claimed
WO-2004098604-A1 THERAPEUTIC AGENTS COMPRISING AN ANTI-ANGIOGENIC AGENT IN COMBINATION WITH AN SRC-INHIBITOR AND THEIR THERAPEUTIC USE ASTRAZENECA AB (SE) 2004-11-18 WO claimed
WO-2004071397-A2 COMBINATION THERAPY OF ZD6474 WITH 5-FU OR/AND CPT-11 ASTRAZENECA AB (SE) 2004-08-26 WO claimed
JP-3522727-B2 2004-04-26 JP claimed
JP-2003513089-A 2003-04-08 JP claimed
EP-1272186-A1 THERAPEUTIC COMBINATIONS OF ANTIHYPERTENSIVE AND ANTIANGIOGENIC AGENTS AstraZeneca AB (SE) 2003-01-08 EP claimed
EP-1244647-A1 QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS AstraZeneca AB (SE) 2002-10-02 EP claimed
WO-2001074360-A1 THERAPEUTIC COMBINATIONS OF ANTIHYPERTENSIVE AND ANTIANGIOGENIC AGENTS ASTRAZENECA AB (SE) 2001-10-11 WO claimed
WO-2001032651-A1 QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS ASTRAZENECA AB (SE) 2001-05-10 WO claimed
EP-3835318-B1 FC-REGION VARIANTS WITH MODIFIED FCRN- AND MAINTAINED PROTEIN A-BINDING PROPERTIES HOFFMANN LA ROCHE (CH) 2025-10-29 EP disclosed
WO-2023212294-A1 ANGIOPOIETIN-RELATED PROTEIN 7-SPECIFIC ANTIBODIES AND USES THEREOF BROADWING BIO LLC (US) 2023-11-02 WO disclosed
WO-2023212293-A1 COMPLEMENT FACTOR H RELATED 4-SPECIFIC ANTIBODIES AND USES THEREOF BROADWING BIO LLC (US) 2023-11-02 WO disclosed
EP-4251206-A1 PROTEIN DERIVATIVES CONTAINING UNNATURAL AMINO ACIDS AND BRANCHED LINKERS Brickbio, Inc. (US) 2023-10-04 EP disclosed
WO-2003039551-A1 COMBINATION THERAPY COMPRISING ZD6474 AND A TAXANE ASTRAZENECA AB (SE) 2003-05-15 WO disclosed
EP-1272186-A1 THERAPEUTIC COMBINATIONS OF ANTIHYPERTENSIVE AND ANTIANGIOGENIC AGENTS AstraZeneca AB (SE) 2003-01-08 EP disclosed
EP-1244647-A1 QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS AstraZeneca AB (SE) 2002-10-02 EP disclosed
WO-2001074360-A1 THERAPEUTIC COMBINATIONS OF ANTIHYPERTENSIVE AND ANTIANGIOGENIC AGENTS ASTRAZENECA AB (SE) 2001-10-11 WO disclosed
WO-2001032651-A1 QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS ASTRAZENECA AB (SE) 2001-05-10 WO disclosed