Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.65 |
| ▸ | EGFR | P00533 | 13/20 | 0.65 |
| ▸ | FLT1 | P17948 | 13/20 | 0.65 |
| ▸ | FGFR1 | P11362 | 12/20 | 0.65 |
| ▸ | FLT4 | P35916 | 11/20 | 0.65 |
| ▸ | RET | P07949 | 2/20 | 0.61 |
| ▸ | KIF5B | P33176 | 2/20 | 0.61 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.54 |
| ▸ | TEK | Q02763 | 2/20 | 0.54 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.54 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.54 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.54 |
| ▸ | PLK4 | O00444 | 1/20 | 0.54 |
| ▸ | CIT | O14578 | 1/20 | 0.54 |
| ▸ | GAK | O14976 | 1/20 | 0.54 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.54 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.54 |
| ▸ | STK10 | O94804 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1008026 | 0.93 | KDR (0.72) | KDREGFRFLT1FGFR1FLT4 | |
| Hydrochloric Acid SCHEMBL6454560 | 0.92 | KDR (0.71) | KDREGFRFLT1FGFR1FLT4 | |
| Water SCHEMBL27735443 | 0.92 | KDR (0.71) | KDREGFRFLT1FGFR1FLT4 | |
| SCHEMBL4604150 | 0.85 | KDR (0.64) | KDREGFRFLT1FGFR1FLT4 | |
| SCHEMBL2200924 | 0.85 | KDR (0.74) | KDREGFRFLT1FGFR1FLT4 | |
| SCHEMBL2203010 | 0.84 | FLT1 (0.73) | KDREGFRFLT1FGFR1FLT4 | |
| Hydrochloric Acid SCHEMBL7477739 | 0.83 | FLT1 (0.75) | KDREGFRFLT1FGFR1FLT4 | |
| SCHEMBL2200083 | 0.83 | EGFR (0.73) | KDREGFRFLT1FGFR1FLT4 | |
| SCHEMBL5506368 | 0.81 | EGFR (0.56) | KDREGFRFLT1FGFR1FLT4 | |
| Trifluoroacetic Acid SCHEMBL2089050 | 0.80 | KDR (0.70) | KDREGFRFLT1FGFR1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1446124-A1 | COMBINATION THERAPY COMPRISING ZD6474 AND A TAXANE | AstraZeneca AB (SE) | 2004-08-18 | — | — | EP | disclosed |
| WO-2003039551-A1 | COMBINATION THERAPY COMPRISING ZD6474 AND A TAXANE | ASTRAZENECA AB (SE) | 2003-05-15 | — | — | WO | disclosed |