Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.64 |
| ▸ | EGFR | P00533 | 13/20 | 0.64 |
| ▸ | FLT1 | P17948 | 12/20 | 0.64 |
| ▸ | FGFR1 | P11362 | 11/20 | 0.64 |
| ▸ | FLT4 | P35916 | 10/20 | 0.64 |
| ▸ | RET | P07949 | 2/20 | 0.59 |
| ▸ | KIF5B | P33176 | 2/20 | 0.59 |
| ▸ | EPHA2 | P29317 | 4/20 | 0.54 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.52 |
| ▸ | TEK | Q02763 | 2/20 | 0.52 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.52 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | CIT | O14578 | 1/20 | 0.52 |
| ▸ | GAK | O14976 | 1/20 | 0.52 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.52 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | STK10 | O94804 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7476474 | 0.93 | KDR (0.63) | KDREGFRFLT1FGFR1FLT4 | |
| SCHEMBL7482777 | 0.91 | KDR (0.62) | KDREGFRFLT1FGFR1FLT4 | |
| SCHEMBL1008026 | 0.85 | KDR (0.72) | KDREGFRFLT1FGFR1FLT4 | |
| Trifluoroacetic Acid SCHEMBL6902285 | 0.85 | KDR (0.65) | KDREGFRFLT1FGFR1FLT4 | |
| Water SCHEMBL27735443 | 0.84 | KDR (0.71) | KDREGFRFLT1FGFR1FLT4 | |
| Hydrochloric Acid SCHEMBL6454560 | 0.84 | KDR (0.71) | KDREGFRFLT1FGFR1FLT4 | |
| SCHEMBL5912648 | 0.79 | ENPP1 (0.43) | KDREGFRFLT1FGFR1FLT4 | |
| SCHEMBL5424040 | 0.78 | KDR (1.00) | KDREGFRFLT1FGFR1FLT4 | |
| SCHEMBL4577163 | 0.78 | EGFR (0.67) | KDREGFR | |
| SCHEMBL31319937 | 0.78 | KDR (0.84) | KDREGFRFLT1FGFR1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943240-A2 | CHEMICAL PROCESS | Astra Zeneca AB (SE) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007036713-A2 | CHEMICAL PROCESS | ASTRAZENECA AB (SE) | 2007-04-05 | — | — | WO | disclosed |
| EP-1446124-A1 | COMBINATION THERAPY COMPRISING ZD6474 AND A TAXANE | AstraZeneca AB (SE) | 2004-08-18 | — | — | EP | disclosed |
| WO-2003039551-A1 | COMBINATION THERAPY COMPRISING ZD6474 AND A TAXANE | ASTRAZENECA AB (SE) | 2003-05-15 | — | — | WO | disclosed |
| EP-1244647-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | AstraZeneca AB (SE) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001032651-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ASTRAZENECA AB (SE) | 2001-05-10 | — | — | WO | disclosed |