Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 9/20 | 0.57 |
| ▸ | CDK2 | P24941 | 9/20 | 0.57 |
| ▸ | CCNA1 | P78396 | 9/20 | 0.57 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.57 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.55 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.55 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.55 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.55 |
| ▸ | CDK4 | P11802 | 3/20 | 0.53 |
| ▸ | CCND3 | P30281 | 3/20 | 0.53 |
| ▸ | GSK3B | P49841 | 3/20 | 0.53 |
| ▸ | PIM1 | P11309 | 2/20 | 0.53 |
| ▸ | MTOR | P42345 | 2/20 | 0.53 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL434273 | 0.87 | TBK1 (0.61) | CCNA2CDK2CCNA1ZAP70STK17A | |
| SCHEMBL10081567 | 0.84 | ZAP70 (0.50) | CCNA2CDK2CCNA1ZAP70STK17A | |
| SCHEMBL10080361 | 0.83 | CCNA2 (0.47) | CCNA2CDK2CCNA1ZAP70STK17A | |
| SCHEMBL10080738 | 0.82 | JAK2 (0.59) | CCNA2CDK2CCNA1CDK4CCND3 | |
| SCHEMBL10081121 | 0.80 | JAK2 (0.57) | CCNA2CDK2CCNA1ZAP70STK17A | |
| SCHEMBL29618397 | 0.78 | CCNA2 (0.65) | CCNA2CDK2CCNA1ZAP70CLK4 | |
| SCHEMBL29618396 | 0.78 | CCNA2 (0.65) | CCNA2CDK2CCNA1ZAP70CLK4 | |
| SCHEMBL15986738 | 0.78 | ZAP70 (0.54) | CCNA2CDK2CCNA1ZAP70STK17A | |
| SCHEMBL10080355 | 0.76 | TBK1 (0.59) | CDK2ZAP70STK17AMYLK4CLK4 | |
| SCHEMBL13467178 | 0.76 | TBK1 (0.52) | ZAP70STK17AMYLK4CLK4TBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012010826-A1 | PYRIMIDINE COMPOUNDS AS INHIBITORS OF PROTEIN KINASES IKK EPSILON AND/OR TBK-1, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMAINEX LIMITED (GB) | 2012-01-26 | — | — | WO | disclosed |