Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 1/20 | 0.65 |
| ▸ | CDK2 | P24941 | 1/20 | 0.65 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.65 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.62 |
| ▸ | ACVR1 | Q04771 | 6/20 | 0.57 |
| ▸ | ABL1 | P00519 | 5/20 | 0.57 |
| ▸ | BCR | P11274 | 4/20 | 0.57 |
| ▸ | PRKCA | P17252 | 3/20 | 0.56 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | PIM1 | P11309 | 1/20 | 0.52 |
| ▸ | CDK4 | P11802 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29618396 | 1.00 | CCNA2 (0.65) | CCNA2CDK2CCNA1ZAP70ACVR1 | |
| SCHEMBL29618440 | 0.90 | ABL1 (0.60) | CCNA2CDK2CCNA1ZAP70ACVR1 | |
| SCHEMBL29618389 | 0.89 | ACVR1 (0.57) | CCNA2CDK2CCNA1ZAP70ACVR1 | |
| SCHEMBL29618360 | 0.88 | ACVR1 (0.54) | CCNA2CDK2CCNA1ZAP70ACVR1 | |
| SCHEMBL29618359 | 0.88 | ACVR1 (0.54) | CCNA2CDK2CCNA1ZAP70ACVR1 | |
| SCHEMBL29618395 | 0.87 | ACVR1 (0.70) | ZAP70ACVR1ABL1BCRPRKCA | |
| SCHEMBL29618422 | 0.87 | JAK2 (0.62) | CDK2ZAP70ACVR1ABL1BCR | |
| SCHEMBL29618431 | 0.87 | ACVR1 (0.58) | CCNA2CDK2CCNA1ZAP70ACVR1 | |
| SCHEMBL7465716 | 0.87 | ACVR1 (0.70) | CCNA2CDK2CCNA1ACVR1ABL1 | |
| SCHEMBL23245924 | 0.84 | ACVR1 (0.50) | CCNA2CDK2CCNA1ZAP70ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114502555-A | Derivatives of 4- (imidazo [1,2-a ] pyridin-3-yl) -N- (pyridin-3-yl) pyrimidin-2-amines for the treatment of proliferative diseases and disorders | 常州千红生化制药股份有限公司 | 2022-05-13 | — | — | CN | disclosed |