Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.61 |
| ▸ | JAK3 | P52333 | 11/20 | 0.52 |
| ▸ | JAK1 | P23458 | 4/20 | 0.50 |
| ▸ | TYK2 | P29597 | 4/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10081121 | 0.92 | JAK2 (0.57) | JAK2JAK3 | |
| SCHEMBL10080738 | 0.91 | JAK2 (0.59) | JAK2 | |
| SCHEMBL15302199 | 0.88 | JAK2 (0.59) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL8086781 | 0.87 | JAK2 (0.74) | JAK2JAK3JAK1TYK2HDAC3 | |
| SCHEMBL12801098 | 0.81 | JAK2 (0.76) | JAK2JAK3JAK1TYK2HDAC3 | |
| SCHEMBL10081114 | 0.80 | TBK1 (0.61) | JAK2JAK3JAK1 | |
| SCHEMBL4383750 | 0.80 | JAK2 (0.78) | JAK2JAK3JAK1TYK2HDAC3 | |
| SCHEMBL434295 | 0.79 | JAK2 (0.57) | JAK2JAK3 | |
| SCHEMBL8236877 | 0.79 | JAK2 (0.75) | JAK2JAK3JAK1TYK2HDAC3 | |
| SCHEMBL4374484 | 0.79 | JAK2 (0.75) | JAK2JAK3JAK1TYK2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012010826-A1 | PYRIMIDINE COMPOUNDS AS INHIBITORS OF PROTEIN KINASES IKK EPSILON AND/OR TBK-1, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMAINEX LIMITED (GB) | 2012-01-26 | — | — | WO | disclosed |