⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL16973350 | 0.98 | — | — | |
| SCHEMBL1766245 | 0.85 | — | — | |
| SCHEMBL17261444 | 0.83 | — | — | |
| Hydrochloric Acid SCHEMBL16961414 | 0.83 | — | — | |
| SCHEMBL31287283 | 0.80 | — | — | |
| SCHEMBL14154886 | 0.78 | — | — | |
| SCHEMBL2301140 | 0.75 | — | — | |
| SCHEMBL7604372 | 0.74 | — | — | |
| Hydrochloric Acid SCHEMBL7615185 | 0.73 | — | — | |
| SCHEMBL2227182 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111511739-B | Dihydropyrimidinyl thiazoles for the treatment and prophylaxis of hepatitis b virus infections | 豪夫迈·罗氏有限公司 | 2023-09-15 | — | — | CN | claimed |
| EP-3732177-B1 | DIHYDROPYRIMIDINYLTHIAZOLE FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | HOFFMANN LA ROCHE (CH) | 2021-11-17 | — | — | EP | claimed |
| WO-2018087345-A1 | COMBINATION THERAPY OF AN HBsAg INHIBITOR, A NUCLEOS(T)IDE ANALOGUE AND AN INTERFERON | F. HOFFMANN-LA ROCHE AG (CH) | 2018-05-17 | — | — | WO | claimed |
| EP-3099685-B1 | NOVEL DIHYDROQUINOLIZINONES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | HOFFMANN LA ROCHE (CH) | 2018-04-18 | — | — | EP | claimed |
| EP-3215504-A1 | NOVEL 6,7-DIHYDROBENZO[A]QUINOLIZIN-2-ONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | F. Hoffmann-La Roche AG (CH) | 2017-09-13 | — | — | EP | claimed |
| WO-2017114812-A1 | COMBINATION THERAPY OF AN HBSAG INHIBITOR AND AN INTERFERON | F. HOFFMANN-LA ROCHE AG (CH) | 2017-07-06 | — | — | WO | claimed |
| WO-2016071215-A1 | NOVEL 6,7-DIHYDROBENZO[A]QUINOLIZIN-2-ONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2016-05-12 | — | — | WO | claimed |
| EP-1003735-A1 | QUINOLIZINE CARBOXYLIC ACID DERIVATIVES | Korea Research Institute of Chemical Technology (KR) | 2000-05-31 | — | — | EP | claimed |
| WO-1999007696-A1 | QUINOLIZINE CARBOXYLIC ACID DERIVATIVES | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 1999-02-18 | — | — | WO | claimed |
| EP-0308019-A2 | 4-Oxo-4H-quinolizine-3-carboxylic acids and derivatives thereof for treating bacterial infections | MERCK & CO. INC. (US) | 1989-03-22 | — | — | EP | claimed |
| CN-118164978-A | Dihydroquinolizinone carboxylic acid compound and application thereof as TRPV4 channel inhibitor | 河北医科大学 | 2024-06-11 | — | — | CN | disclosed |
| CN-111511739-B | Dihydropyrimidinyl thiazoles for the treatment and prophylaxis of hepatitis b virus infections | 豪夫迈·罗氏有限公司 | 2023-09-15 | — | — | CN | disclosed |
| CN-116196411-A | PAPD5 and PAPD7 inhibitors for the treatment of hepatitis B infection | 豪夫迈·罗氏有限公司 | 2023-06-02 | — | — | CN | disclosed |
| CN-109328237-B | Inhibitors of PAPD5 and PAPD7 for the treatment of hepatitis b infection | 豪夫迈·罗氏有限公司 | 2022-12-06 | — | — | CN | disclosed |
| CN-111943946-B | Dihydroquinazinone carboxylic acid compound containing nitrogen heterocyclic segment and application thereof | 中国医学科学院医药生物技术研究所 | 2022-07-01 | — | — | CN | disclosed |
| WO-1999007696-A1 | QUINOLIZINE CARBOXYLIC ACID DERIVATIVES | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 1999-02-18 | — | — | WO | disclosed |
| EP-0871628-A1 | QUINOLIZINONE TYPE COMPOUNDS | Abbott Laboratories (US) | 1998-10-21 | — | — | EP | disclosed |
| WO-1998038191-A1 | PROCESS FOR PREPARATION OF 4H-4-OXO-QUINOLIZINE-3-CARBOXYLIC ACID DERIVATIVES | ABBOTT LABORATORIES (US) | 1998-09-03 | — | — | WO | disclosed |
| WO-1996039407-A1 | QUINOLIZINONE TYPE COMPOUNDS | ABBOTT LABORATORIES (US) | 1996-12-12 | — | — | WO | disclosed |
| CN-1137273-A | Quinolizinone type compounds | ABBOTT LAB (US) | 1996-12-04 | — | — | CN | disclosed |