Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | CASP7 | P55210 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL28122664 | 0.98 | KDM4E (0.33) | KDM4EMEN1ALDH1A1MAPTHPGD | |
| Water SCHEMBL28122070 | 0.98 | KDM4E (0.33) | KDM4EMEN1ALDH1A1MAPTHPGD | |
| Hydrochloric Acid SCHEMBL16973351 | 0.98 | THRB (0.32) | KMT2A | |
| SCHEMBL28021022 | 0.87 | KDM4E (0.31) | KDM4EMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL1766246 | 0.84 | — | — | |
| Hydrochloric Acid SCHEMBL16961416 | 0.83 | — | — | |
| SCHEMBL17261445 | 0.81 | HDAC4 (0.33) | — | |
| SCHEMBL28122665 | 0.80 | CHRM3 (0.37) | — | |
| Water SCHEMBL28838534 | 0.79 | CHRM3 (0.36) | — | |
| Hydrochloric Acid SCHEMBL30571057 | 0.79 | CHRM3 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111511739-B | Dihydropyrimidinyl thiazoles for the treatment and prophylaxis of hepatitis b virus infections | 豪夫迈·罗氏有限公司 | 2023-09-15 | — | — | CN | claimed |
| EP-3732177-B1 | DIHYDROPYRIMIDINYLTHIAZOLE FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | HOFFMANN LA ROCHE (CH) | 2021-11-17 | — | — | EP | claimed |
| WO-2018087345-A1 | COMBINATION THERAPY OF AN HBsAg INHIBITOR, A NUCLEOS(T)IDE ANALOGUE AND AN INTERFERON | F. HOFFMANN-LA ROCHE AG (CH) | 2018-05-17 | — | — | WO | claimed |
| EP-3099685-B1 | NOVEL DIHYDROQUINOLIZINONES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | HOFFMANN LA ROCHE (CH) | 2018-04-18 | — | — | EP | claimed |
| CN-106543170-B | The carboxylate of 8 chlorine, 1 cyclopropyl, 7 fluorine, 9 methyl, 4 oxygen, 4 hydrogen quinolizine 3 and its synthetic method | 丹诺医药(苏州）有限公司 | 2018-02-23 | — | — | CN | claimed |
| CN-107207505-A | New 2 oxo 6,7 dihydrobenzo [a] quinolizine 3 formic acid derivates hepatitis b virus infected for treating and preventing | 豪夫迈·罗氏有限公司 | 2017-09-26 | — | — | CN | claimed |
| EP-3215504-A1 | NOVEL 6,7-DIHYDROBENZO[A]QUINOLIZIN-2-ONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | F. Hoffmann-La Roche AG (CH) | 2017-09-13 | — | — | EP | claimed |
| CN-107108606-A | New 6,7 dihydrobenzos [a] quinolizine 2 ketone derivatives hepatitis b virus infected for treating and preventing | 豪夫迈·罗氏有限公司 | 2017-08-29 | — | — | CN | claimed |
| WO-2017114812-A1 | COMBINATION THERAPY OF AN HBSAG INHIBITOR AND AN INTERFERON | F. HOFFMANN-LA ROCHE AG (CH) | 2017-07-06 | — | — | WO | claimed |
| CN-106543170-A | 8 chlorine, 1 cyclopropyl, 7 fluorine, 9 methyl, 4 oxygen, 4 hydrogen quinolizine, 3 carboxylate and its synthetic method | 丹诺医药(苏州）有限公司 | 2017-03-29 | — | — | CN | claimed |
| CN-105899508-A | Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis B virus infection | 豪夫迈·罗氏有限公司 | 2016-08-24 | — | — | CN | claimed |
| WO-2016071215-A1 | NOVEL 6,7-DIHYDROBENZO[A]QUINOLIZIN-2-ONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2016-05-12 | — | — | WO | claimed |
| EP-1003735-A1 | QUINOLIZINE CARBOXYLIC ACID DERIVATIVES | Korea Research Institute of Chemical Technology (KR) | 2000-05-31 | — | — | EP | claimed |
| WO-1999007696-A1 | QUINOLIZINE CARBOXYLIC ACID DERIVATIVES | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 1999-02-18 | — | — | WO | claimed |
| EP-0308019-A2 | 4-Oxo-4H-quinolizine-3-carboxylic acids and derivatives thereof for treating bacterial infections | MERCK & CO. INC. (US) | 1989-03-22 | — | — | EP | claimed |
| CN-118164978-A | Dihydroquinolizinone carboxylic acid compound and application thereof as TRPV4 channel inhibitor | 河北医科大学 | 2024-06-11 | — | — | CN | disclosed |
| CN-111511739-B | Dihydropyrimidinyl thiazoles for the treatment and prophylaxis of hepatitis b virus infections | 豪夫迈·罗氏有限公司 | 2023-09-15 | — | — | CN | disclosed |
| EP-0308019-A3 | 4-OXO-4H-QUINOLIZINE-3-CARBOXYLIC ACIDS AND DERIVATIVES THEREOF FOR TREATING BACTERIAL INFECTIONS | MERCK & CO. INC. (US) | 1991-09-25 | — | — | EP | disclosed |
| EP-0308019-A2 | 4-Oxo-4H-quinolizine-3-carboxylic acids and derivatives thereof for treating bacterial infections | MERCK & CO. INC. (US) | 1989-03-22 | — | — | EP | disclosed |
| EP-0308019-A2 | 4-Oxo-4H-quinolizine-3-carboxylic acids and derivatives thereof for treating bacterial infections | MERCK & CO. INC. (US) | 1989-03-22 | — | — | EP | disclosed |