Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 7/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 4/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 2/20 | 0.42 |
| ▸ | CTSK | P43235 | 2/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12932561 | 0.89 | CAPN1 (0.47) | CAPN1ALDH1A1HPGDKDM4ELMNA | |
| SCHEMBL12900396 | 0.89 | PTGER4 (0.51) | ATML3MBTL1ALDH1A1HPGDKDM4E | |
| SCHEMBL12900478 | 0.87 | ALDH1A1 (0.45) | CAPN1ATML3MBTL1ALDH1A1HPGD | |
| SCHEMBL8272709 | 0.76 | HPGD (0.48) | ALDH1A1HPGDKDM4ELMNAHSD17B10 | |
| SCHEMBL3695188 | 0.73 | ALDH1A1 (0.78) | ALDH1A1HPGDKDM4ELMNAHSD17B10 | |
| SCHEMBL18837529 | 0.73 | ALDH1A1 (0.78) | ALDH1A1HPGDKDM4ELMNAHSD17B10 | |
| SCHEMBL9798108 | 0.71 | TRPA1 (0.56) | ALDH1A1HPGDKDM4ESMN1; SMN2GAA | |
| SCHEMBL10496478 | 0.71 | TRPA1 (0.56) | ALDH1A1HPGDKDM4ESMN1; SMN2GAA | |
| SCHEMBL12932989 | 0.71 | PTGER4 (0.68) | — | |
| SCHEMBL12931824 | 0.71 | PARP1 (0.45) | ALDH1A1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2460787-A1 | Amide compounds and their use as PGE2 antagonists. | Astellas Pharma Inc. (JP) | 2012-06-06 | — | — | EP | disclosed |