Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | CASP1 | P29466 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | SPR | P35270 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22478566 | 0.90 | ALDH1A1 (0.67) | ALDH1A1KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL18549350 | 0.88 | ALDH1A1 (0.57) | ALDH1A1KDM4EHPGDHSD17B10ALOX15 | |
| SCHEMBL18548900 | 0.87 | LMNA (0.58) | ALDH1A1KDM4EHPGDHSD17B10ALOX15 | |
| SCHEMBL18548838 | 0.86 | KDM4E (0.50) | ALDH1A1KDM4EHPGDHSD17B10ALOX15 | |
| SCHEMBL10085034 | 0.86 | LMNA (0.55) | ALDH1A1KDM4EHPGDHSD17B10ALOX15 | |
| SCHEMBL20291770 | 0.85 | SMN1; SMN2 (0.57) | ALDH1A1KDM4EHPGDHSD17B10ALOX15 | |
| SCHEMBL21412857 | 0.83 | POLB (0.57) | ALDH1A1KDM4EHPGDHSD17B10ALOX15 | |
| SCHEMBL30001052 | 0.83 | POLB (0.57) | ALDH1A1KDM4EHPGDHSD17B10ALOX15 | |
| SCHEMBL10086141 | 0.81 | KDM4E (0.48) | ALDH1A1KDM4EHPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL10084838 | 0.80 | LMNA (0.55) | ALDH1A1KDM4EHPGDHSD17B10ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590975-B1 | INDOLIZINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2015-08-19 | — | — | EP | disclosed |
| WO-2012004731-A1 | INDOLIZINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-01-12 | — | — | WO | disclosed |