Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | TP53 | P04637 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3135906 | 1.00 | TDP1 (0.56) | TDP1ALDH1A1TP53TSHRMEN1 | |
| SCHEMBL3133801 | 1.00 | TDP1 (0.56) | TDP1ALDH1A1TP53TSHRMEN1 | |
| SCHEMBL3144279 | 0.98 | TDP1 (0.58) | TDP1ALDH1A1TP53TSHRMEN1 | |
| SCHEMBL2717675 | 0.91 | TDP1 (0.61) | TDP1ALDH1A1TP53TSHRMEN1 | |
| SCHEMBL2718376 | 0.87 | TDP1 (0.47) | TDP1ALDH1A1TP53TSHRMEN1 | |
| SCHEMBL28371656 | 0.86 | HRH3 (0.51) | TDP1ALDH1A1TP53TSHRMEN1 | |
| SCHEMBL2828673 | 0.85 | TDP1 (0.42) | TDP1ALDH1A1TP53TSHRMEN1 | |
| SCHEMBL2719131 | 0.85 | TDP1 (0.42) | TDP1ALDH1A1TP53TSHRMEN1 | |
| SCHEMBL10179933 | 0.85 | TDP1 (0.54) | TDP1ALDH1A1TP53TSHRMEN1 | |
| SCHEMBL3143601 | 0.85 | TDP1 (0.54) | TDP1ALDH1A1TP53TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693545-A | Organosilicon polymer compound and organosilicon polymer material | 国立大学法人大阪大学 | 2024-03-12 | — | — | CN | disclosed |
| EP-3522877-B1 | SMALL MOLECULE AMPK ACTIVATORS | UNIV PITTSBURGH COMMONWEALTH SYS HIGHER EDUCATION (US) | 2023-12-06 | — | — | EP | disclosed |
| US-11673853-B2 | Small molecule AMPK activators | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2023-06-13 | — | — | US | disclosed |
| CN-111801355-B | Polymer material and method for producing same | 国立大学法人大阪大学 | 2023-02-28 | — | — | CN | disclosed |
| CN-110959023-B | Prepreg and carbon fiber-reinforced composite material | 东丽株式会社 | 2022-08-23 | — | — | CN | disclosed |
| US-20220153685-A1 | SMALL MOLECULE AMPK ACTIVATORS | THE UNITED STATES AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS TECHNOLOGY TRANSFER PROGRAM (10P9TT) | 2022-05-19 | — | — | US | disclosed |
| CN-110446745-B | Prepreg and carbon fiber reinforced composite material | 东丽株式会社 | 2022-05-13 | — | — | CN | disclosed |
| US-11040935-B2 | Small molecule AMPK activators | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2021-06-22 | — | — | US | disclosed |
| WO-2021045203-A1 | POLYMER MATERIAL AND PRODUCTION METHOD THEREFOR | 国立大学法人大阪大学 | 2021-03-11 | — | — | WO | disclosed |
| CN-112041380-A | Prepreg and carbon fiber-reinforced composite material | 东丽株式会社 | 2020-12-04 | — | — | CN | disclosed |
| EP-2137193-B1 | SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF | SANOFI SA (FR) | 2017-08-09 | — | — | EP | disclosed |
| EP-2268645-B1 | SUBSTITUTED DIHYDRO, TRIHYDRO AND TETRAHYDRO CYCLOALKYLOXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF AS ALLOSTERIC MODULATORS OF MGLUR | SANOFI SA (FR) | 2014-11-12 | — | — | EP | disclosed |
| US-8642603-B2 | Substituted dihydro and tetrahydro oxazolopyrimidinones, preparation and use thereof | SANOFI (FR) | 2014-02-04 | — | — | US | disclosed |
| US-8207181-B2 | Substituted dihydro, trihydro and tetrahydro cycloalkyloxazolopyrimidinones, preparation and use thereof | SANOFI (FR) | 2012-06-26 | — | — | US | disclosed |
| US-20110077257-A1 | SUBSTITUTED DIHYDRO, TRIHYDRO AND TETRAHYDRO CYCLOALKYLOXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF | SANOFI-AVENTIS (FR) | 2011-03-31 | — | — | US | disclosed |
| EP-2268645-A1 | SUBSTITUTED DIHYDRO, TRIHYDRO AND TETRAHYDRO CYCLOALKYLOXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF AS ALLOSTERIC MODULATORS OF MGLUR | Sanofi-Aventis (FR) | 2011-01-05 | — | — | EP | disclosed |
| US-20100075994-A1 | SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF | SANOFI-AVENTIS (FR) | 2010-03-25 | — | — | US | disclosed |
| EP-2137193-A2 | SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF | Sanofi-Aventis (FR) | 2009-12-30 | — | — | EP | disclosed |
| WO-2009110901-A1 | SUBSTITUTED DIHYDRO, TRIHYDRO AND TETRAHYDRO CYCLOALKYLOXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF AS ALLOSTERIC MODULATORS OF MGLUR | SANOFI-AVENTIS (FR) | 2009-09-11 | — | — | WO | disclosed |
| WO-2008112483-A2 | SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF | SANOFI-AVENTIS (FR) | 2008-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11673853-B2 | Small molecule AMPK activators | PRKAG1, PRKAG2, PRKAA1 | TDP1 3123/4885ALDH1A1 2770/4885TP53 761/4885 |
| US-20110077257-A1 | SUBSTITUTED DIHYDRO, TRIHYDRO AND TETRAHYDRO CYCLOALKYLOXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF | CNR2, CNR1, GRIN2B | TDP1 1935/4885ALDH1A1 2209/4885TP53 4885/4885 |
| US-20220153685-A1 | SMALL MOLECULE AMPK ACTIVATORS | PRKAG1, PRKAG2, PRKAA1 | TDP1 3123/4885ALDH1A1 2770/4885TP53 761/4885 |
| US-20100075994-A1 | SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF | GRM2, GRM1, GRIN2C | TDP1 1955/4885ALDH1A1 1875/4885TP53 4885/4885 |
| US-11040935-B2 | Small molecule AMPK activators | PRKAG1, PRKAG2, PRKAA1 | TDP1 3123/4885ALDH1A1 2770/4885TP53 761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.