Sugi Predict

Sugi Predict / Targets / PRKAG2

PRKAG2

5'-AMP-activated protein kinase subunit gamma-2 · Q9UGJ0 · PRKAG2 on Sugi Atlas →

46,444 patent compounds predicted against PRKAG2, 28,249 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL61579 SCHEMBL61579 0.51 12/20
SCHEMBL176936 SCHEMBL176936 0.55 11/20
SCHEMBL61866 SCHEMBL61866 0.51 10/20
SCHEMBL68693 SCHEMBL68693 0.47 10/20
SCHEMBL62208 SCHEMBL62208 0.51 9/20
Trifluoroacetic Acid Trifluoroacetic Acid (SCHEMBL63390) 0.49 9/20
SCHEMBL91078 SCHEMBL91078 0.59 8/20
SCHEMBL229119 SCHEMBL229119 0.54 8/20
SCHEMBL61772 SCHEMBL61772 0.53 8/20
SCHEMBL260615 SCHEMBL260615 0.45 8/20
SCHEMBL176882 SCHEMBL176882 0.63 7/20
SCHEMBL61677 SCHEMBL61677 0.57 7/20
SCHEMBL159594 SCHEMBL159594 0.53 7/20
SCHEMBL228817 SCHEMBL228817 0.52 7/20
SCHEMBL230173 SCHEMBL230173 0.52 7/20
SCHEMBL61254 SCHEMBL61254 0.45 7/20
SCHEMBL261067 SCHEMBL261067 0.45 7/20
Dorsomorphin Dorsomorphin (SCHEMBL463155) 1.00 6/20
SCHEMBL157758 SCHEMBL157758 0.58 6/20
SCHEMBL228213 SCHEMBL228213 0.56 6/20

Clinical trials — most relevant to PRKAG2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Short-Term Metformin Use in Young, Healthy Adults: Impacts on Exercise Capacity PHASE4COMPLETED
Alpha Ketoglutarate Enhances Geroprotection In Surgery (AEGIS) PHASE4RECRUITING
Metformin Induces a Dietary Restriction-like State in Human PHASE4UNKNOWN
Status of Growth Hormone/ Insulin-like Growth Factor-1 (GH/IGF-1) Axis and Growth Failure in Ataxia Telangiectasia (AT) PHASE4UNKNOWN
Clinical Evaluation of the Effect of Metformin in Sepsis PHASE3UNKNOWN
Metformin and Simvastatin Use in Bladder Cancer PHASE2UNKNOWN
Metformin as a Novel Therapy for Autosomal Dominant Polycystic Kidney Disease PHASE2COMPLETED
Effects of Roflumilast on Insulin and Blood Sugar Levels in Prediabetic Overweight and Obese Individuals PHASE1/PHASE2COMPLETED
Safety and Feasibility of Metformin for Sepsis Induced AKI PHASE2COMPLETED
Efficacy of Amlexanox vs. Placebo in Type 2 Diabetic Patients PHASE2COMPLETED
Metformin for Fibromyalgia Symptoms (INFORM Trial) PHASE2RECRUITING
PKC412 and 5-Azacytidine PHASE1/PHASE2COMPLETED
The Effect of Addition of Metformin In Obese Non- Diabetic Patients With Heart Failure With Preserved Ejection Fraction PHASE2UNKNOWN
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma PHASE1COMPLETED
Sirolimus and Gold Sodium Thiomalate in Treating Patients With Advanced Squamous Non-Small Cell Lung Cancer PHASE1WITHDRAWN
Metformin's Effect on Glucagon-induced Glucose Production and Protein Metabolism. PHASE1COMPLETED
Pre-Surgical Trial of the Combination of Metformin and Atorvastatin in Newly Diagnosed Operable Breast Cancer EARLY_PHASE1COMPLETED
Effect of Age on Glucose and Lipid Metabolism nanCOMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
Cardiac and Skeletal Muscle Energy Metabolism in Abnormal Growth Hormone States nanCOMPLETED
Intravenous Terbutaline in Severe Status Asthmaticus nanUNKNOWN
NASH AMPK Exercise Dosing (AMPED) Trial nanRECRUITING
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation nanCOMPLETED
Influence of Intermittent Hypoxia on Glycemic Control nanCOMPLETED
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men nanRECRUITING
Skeletal Muscle Mitochondrial Abnormalities and the Metabolic Syndrome in PAH nanCOMPLETED
Defective Atypical Protein Kinase C (PKC) Activation in Diabetes and Metabolic Syndrome nanCOMPLETED
The Effect of White Tea Consumption on Obesity nanCOMPLETED
Duality of Lipids: the Athlete's Paradox nanCOMPLETED
Study of Menstrual Irregularities and Endometrial Pathology in Women Undergoing Bariatric Surgery nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a PRKAG2 binder may also engage these)

ProteinNameSimilarity
Q91WG5 — 1.000 Q91WG5 →
Q5R4S0 — 0.999 Q5R4S0 →
O43078 — 0.993 O43078 →
O13965 — 0.992 O13965 →
Q5A744 — 0.992 Q5A744 →
O75011 — 0.992 O75011 →
A7KAK6 — 0.992 A7KAK6 →
A2QHV0 — 0.990 A2QHV0 →
Q06321 — 0.990 Q06321 →
B3M301 — 0.990 B3M301 →
Q6E3D4 — 0.990 Q6E3D4 →
Q6CUA5 — 0.989 Q6CUA5 →
Q9Y7P6 — 0.989 Q9Y7P6 →
G5EFD2 — 0.989 G5EFD2 →
Q23356 — 0.989 Q23356 →
Q10149 — 0.989 Q10149 →
A5DNL9 — 0.989 A5DNL9 →
Q92539 — 0.989 Q92539 →
Q9LT75 — 0.989 Q9LT75 →
B2MZD0 — 0.988 B2MZD0 →
Q09826 — 0.988 Q09826 →
P81299 — 0.988 P81299 →
P48479 — 0.988 P48479 →
P40433 — 0.988 P40433 →
C5DX31 — 0.988 C5DX31 →
A8XQD5 — 0.988 A8XQD5 →
B4NBP4 — 0.988 B4NBP4 →
Q6CAP3 — 0.988 Q6CAP3 →
Q08960 — 0.988 Q08960 →
O59763 — 0.988 O59763 →