Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB3 | P54753 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 8/20 | 0.46 |
| ▸ | NPC1 | O15118 | 7/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.45 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10086803 | 0.82 | NPC1 (0.56) | EPHB3MAPTRAB9ANPC1KIT | |
| SCHEMBL10086773 | 0.82 | RAB9A (0.44) | EPHB3LMNAMEN1KMT2ARAB9A | |
| SCHEMBL1683591 | 0.82 | KDM4E (0.50) | EPHB3MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL10086778 | 0.82 | EPHB3 (0.45) | EPHB3KMT2ARAB9ANPC1KIT | |
| SCHEMBL1684347 | 0.80 | RAB9A (0.50) | EPHB3LMNAMAPTMEN1KMT2A | |
| SCHEMBL9286069 | 0.79 | EPHB3 (0.52) | EPHB3MAPTRAB9ANPC1KIT | |
| SCHEMBL9289501 | 0.79 | EPHB3 (0.52) | EPHB3MAPTRAB9ANPC1KIT | |
| SCHEMBL29843826 | 0.77 | EPHB3 (0.56) | EPHB3LMNAMAPTRAB9ANPC1 | |
| SCHEMBL1682619 | 0.77 | EPHB3 (0.46) | EPHB3KLKB1RAB9ANPC1KIT | |
| SCHEMBL10086770 | 0.77 | EPHB3 (0.60) | EPHB3LMNAMAPTKLKB1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012045729-A1 | IMIDAZO [1, 2 -A] PYRIDINE AND PYRAZOLO [1, 5 -A] PYRIDINE DERIVATIVES AS TRPV1 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2012-04-12 | — | — | WO | disclosed |