Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.33 |
| ▸ | S100A9 | P06702 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.32 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.32 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.32 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.32 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.32 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.32 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL335184 | 0.78 | ALDH1A1 (0.41) | TDP1KDM4EALDH1A1POLBS100A9 | |
| SCHEMBL1008889 | 0.76 | POLB (0.42) | TDP1KDM4EALDH1A1POLBS100A9 | |
| SCHEMBL15157663 | 0.76 | ALDH1A1 (0.36) | TDP1KDM4EALDH1A1POLBTBK1 | |
| SCHEMBL16879533 | 0.75 | ALDH1A1 (0.41) | KDM4EALDH1A1POLBS100A9HTT | |
| SCHEMBL10314907 | 0.75 | ALDH1A1 (0.41) | TDP1KDM4EALDH1A1POLBS100A9 | |
| SCHEMBL1010296 | 0.75 | KDM4E (0.41) | TDP1KDM4EALDH1A1POLBS100A9 | |
| SCHEMBL1060088 | 0.72 | ALDH1A1 (0.40) | TDP1KDM4EALDH1A1POLBMAOB | |
| SCHEMBL12499186 | 0.71 | ADRA1D (0.51) | KDM4EALDH1A1CA2ARADRA1D | |
| SCHEMBL22561720 | 0.71 | KDM4E (0.38) | KDM4EALDH1A1POLB | |
| SCHEMBL22713562 | 0.71 | KDM4E (0.38) | KDM4EALDH1A1POLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268618-A1 | COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS | IRM LLC (BM) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009111337-A1 | COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS | IRM LLC (BM) | 2009-09-11 | — | — | WO | disclosed |