SCHEMBL10089882

SCHEMBL10089882

Cc1c(F)ccc(C(=O)NCc2cccc(Cl)c2)c1NC(=O)c1cc(Cn2nnc(C(F)(F)F)n2)nn1-c1ncccc1Cl

nearest known ligand 0.42

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MMP13 P45452 4/20 0.38
POLB P06746 1/20 0.37
LMNA P02545 1/20 0.36
HPGD P15428 1/20 0.36
PPARG P37231 2/20 0.35
CNR2 P34972 1/20 0.35
CCR1 P32246 5/20 0.34
NTRK1 P04629 1/20 0.34
NPC1 O15118 1/20 0.34
MEN1 O00255 1/20 0.33
HCRTR1 O43613 1/20 0.33
KMT2A Q03164 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15905592 0.94 DHODH (0.37) MMP13PPARGCNR2CCR1NTRK1
SCHEMBL10089982 0.93 PPARG (0.39) PPARG
SCHEMBL10089924 0.92 MMP13 (0.38) MMP13POLBLMNAHPGDPPARG
SCHEMBL10090038 0.92 PPARG (0.35) MMP13PPARGNTRK1
SCHEMBL10090043 0.92 MMP13 (0.38) MMP13POLBLMNAHPGDPPARG
SCHEMBL10089986 0.91 MAPK8 (0.39) HPGDPPARGCNR2NTRK1MEN1
SCHEMBL10090033 0.90 PDE2A (0.35) HPGDPPARG
SCHEMBL10090020 0.88 MMP13 (0.38) MMP13LMNAHPGDPPARGCCR1
SCHEMBL10090009 0.88 MMP13 (0.38) MMP13POLBLMNAHPGDCNR2
SCHEMBL10089984 0.88 MMP13 (0.38) MMP13POLBLMNAHPGDCNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8791143-B2 Anthranilic diamide derivatives having cyclic side-chains BAYER CROPSCIENCE AG (DE) 2014-07-29 US disclosed
US-20120010249-A1 Anthranilic diamide derivatives having cyclic side-chains BAYER CROPSCIENCE AG (DE) 2012-01-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120010249-A1 Anthranilic diamide derivatives having cyclic side-chains DDT, ADCY1, ANTXR2 MMP13 4356/4885POLB 3967/4885LMNA 2979/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.