SCHEMBL10089956

SCHEMBL10089956

O=C(NCc1ccccc1Cl)c1cc2ccccc2c(Cl)c1NC(=O)c1cc(Cn2nnc(C(F)(F)F)n2)nn1-c1ncccc1Cl

nearest known ligand 0.38

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
LMNA P02545 2/20 0.36
THRB P10828 1/20 0.36
CNR2 P34972 1/20 0.34
MAPK8 P45983 3/20 0.34
TP53 P04637 3/20 0.34
KDM4E B2RXH2 1/20 0.34
PKM P14618 1/20 0.34
HSD17B10 Q99714 1/20 0.34
NPC1 O15118 1/20 0.33
NR3C1 P04150 1/20 0.33
MAPT P10636 1/20 0.33
SLC16A3 O15427 1/20 0.32
SLC16A1 P53985 1/20 0.32
MCTS1 Q9ULC4 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10089946 0.93 HSD17B13 (0.39)
SCHEMBL10090040 0.93 EGLN1 (0.36) LMNACNR2KDM4E
SCHEMBL10089966 0.92 MMP13 (0.37) MEN1KMT2ALMNACNR2TP53
SCHEMBL10090006 0.90 PTGER4 (0.37) KDM4E
SCHEMBL17122543 0.89 IDH1 (0.33)
SCHEMBL10090007 0.89 ABCB1 (0.39) SLC16A3SLC16A1MCTS1
SCHEMBL17122545 0.88 MAPK8 (0.38) MEN1KMT2ACNR2MAPK8TP53
SCHEMBL10090049 0.88 MEN1 (0.36) MEN1KMT2ALMNATHRBCNR2
SCHEMBL10089841 0.87 TP53 (0.38) MEN1KMT2ACNR2MAPK8TP53
SCHEMBL10089986 0.85 MAPK8 (0.39) MEN1KMT2ACNR2MAPK8TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2582695-B1 ANTHRANILIC ACID DIAMIDE DERIVATIVES WITH CYCLICAL SIDE CHAINS BAYER IP GMBH (DE) 2015-09-30 EP disclosed
US-8791143-B2 Anthranilic diamide derivatives having cyclic side-chains BAYER CROPSCIENCE AG (DE) 2014-07-29 US disclosed
US-20120010249-A1 Anthranilic diamide derivatives having cyclic side-chains BAYER CROPSCIENCE AG (DE) 2012-01-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120010249-A1 Anthranilic diamide derivatives having cyclic side-chains DDT, ADCY1, ANTXR2 MEN1 1632/4885KMT2A 961/4885LMNA 2979/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.