SCHEMBL10089970

SCHEMBL10089970

Cc1cc(C#N)cc(C(=O)NCc2ccccc2OC(F)F)c1NC(=O)c1cc(Cn2nnc(C(F)(F)F)n2)nn1-c1ncccc1Cl

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
GPR6 P46095 1/20 0.36
MAPK8 P45983 1/20 0.33
SLC2A1 P11166 2/20 0.31
SLC2A3 P11169 2/20 0.31
SLC2A4 P14672 2/20 0.31
LIPG Q9Y5X9 1/20 0.31
EPHX2 P34913 1/20 0.31
SLC2A2 P11168 1/20 0.31
CACNA1G O43497 2/20 0.31
CACNA1H O95180 2/20 0.31
HSD17B13 Q7Z5P4 1/20 0.31
SLC16A3 O15427 1/20 0.31
SLC16A1 P53985 1/20 0.31
MCTS1 Q9ULC4 1/20 0.31
PDE5A O76074 2/20 0.31
TP53 P04637 1/20 0.31
P2RY12 Q9H244 1/20 0.31
MAPK1 P28482 1/20 0.31
DHODH Q02127 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10090012 0.93 HSD17B13 (0.38) GPR6MAPK8EPHX2HSD17B13MAPK1
SCHEMBL10089901 0.93 MAPK8 (0.34) GPR6MAPK8LIPGEPHX2CACNA1G
SCHEMBL10090041 0.93 GPR6 (0.34) GPR6SLC2A1SLC2A3SLC2A4EPHX2
SCHEMBL10089906 0.93 GPR6 (0.34) GPR6SLC2A1SLC2A3SLC2A4EPHX2
SCHEMBL10090004 0.92 GPR6 (0.38) GPR6MAPK8LIPGEPHX2HSD17B13
SCHEMBL10089975 0.90 SLC2A1 (0.35) GPR6SLC2A1SLC2A3SLC2A4SLC2A2
SCHEMBL10090042 0.90 GPR6 (0.35) GPR6SLC2A1SLC2A3SLC2A4SLC2A2
SCHEMBL15488987 0.89 CACNA1H (0.34) GPR6SLC2A1SLC2A3SLC2A4SLC2A2
SCHEMBL10089933 0.89 SLC2A1 (0.37) SLC2A1SLC2A3SLC2A4SLC2A2DHODH
SCHEMBL13085113 0.88 SLC2A1 (0.34) SLC2A1SLC2A3SLC2A4SLC2A2CACNA1H

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2582695-B1 ANTHRANILIC ACID DIAMIDE DERIVATIVES WITH CYCLICAL SIDE CHAINS BAYER IP GMBH (DE) 2015-09-30 EP disclosed
US-8791143-B2 Anthranilic diamide derivatives having cyclic side-chains BAYER CROPSCIENCE AG (DE) 2014-07-29 US disclosed
US-20120010249-A1 Anthranilic diamide derivatives having cyclic side-chains BAYER CROPSCIENCE AG (DE) 2012-01-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120010249-A1 Anthranilic diamide derivatives having cyclic side-chains DDT, ADCY1, ANTXR2 GPR6 2424/4885MAPK8 4028/4885SLC2A1 3782/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.