Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK2 | Q16620 | 1/20 | 0.56 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
| ▸ | PRKAA1 | Q13131 | 9/20 | 0.49 |
| ▸ | KDR | P35968 | 9/20 | 0.49 |
| ▸ | PRKAA2 | P54646 | 8/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.49 |
| ▸ | FLT3 | P36888 | 3/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | NEK2 | P51955 | 1/20 | 0.44 |
| ▸ | MELK | Q14680 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL397241 | 1.00 | NTRK2 (0.56) | NTRK2RETPRKAA1KDRPRKAA2 | |
| SCHEMBL10091908 | 0.94 | FLT3 (0.54) | NTRK2RETPRKAA1KDRPRKAA2 | |
| SCHEMBL397630 | 0.94 | FLT3 (0.54) | NTRK2RETPRKAA1KDRPRKAA2 | |
| SCHEMBL394152 | 0.93 | PDGFRB (0.54) | NTRK2RETPRKAA1KDRPRKAA2 | |
| SCHEMBL10091910 | 0.93 | PDGFRB (0.54) | NTRK2RETPRKAA1KDRPRKAA2 | |
| SCHEMBL4128689 | 0.90 | RET (0.55) | NTRK2RETKDRPDGFRBFGFR1 | |
| SCHEMBL4128697 | 0.90 | RET (0.55) | NTRK2RETKDRPDGFRBFGFR1 | |
| SCHEMBL393782 | 0.88 | NTRK2 (0.64) | NTRK2RETPRKAA1KDRPRKAA2 | |
| SCHEMBL10091883 | 0.88 | NTRK2 (0.64) | NTRK2RETPRKAA1KDRPRKAA2 | |
| SCHEMBL393047 | 0.86 | NTRK2 (0.61) | NTRK2RETPRKAA1KDRPRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101608-B2 | 3-(4-Methyl-imidazol-1-yl)-N-{3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-5-trifluoromethyl-benzamide; including benign and malignant proliferative disorders as well as diseases resulting from inappropriate activation of the immune and nervous systems | IRM LLC, a Delware Limited Corporation (BM) | 2012-01-24 | — | — | US | disclosed |
| US-20080221192-A1 | Compounds and Compositions as Protein Kinase Inhibitors | IRM LLC (BM) | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221192-A1 | Compounds and Compositions as Protein Kinase Inhibitors | BMX, FRK, PTK2B | NTRK2 235/4885RET 5/4885PRKAA1 237/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.