Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC5 | Q9UL62 | 7/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | TRPC4 | Q9UBN4 | 1/20 | 0.54 |
| ▸ | AR | P10275 | 1/20 | 0.51 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.39 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1009123 | 0.73 | AR (0.49) | TRPC5KCNH2TRPC4ARAKR1B1 | |
| SCHEMBL20832175 | 0.73 | TRPC5 (0.76) | TRPC5KCNH2TRPC4TIPARPALDH1A1 | |
| SCHEMBL24176690 | 0.73 | TRPC5 (0.65) | TRPC5KCNH2TRPC4ALDH1A1 | |
| SCHEMBL24176691 | 0.73 | TRPC5 (0.65) | TRPC5KCNH2TRPC4ALDH1A1 | |
| SCHEMBL1009667 | 0.72 | TRPC5 (0.43) | TRPC5KCNH2TRPC4PKMTRPA1 | |
| SCHEMBL24176723 | 0.72 | TRPC5 (0.64) | TRPC5KCNH2TRPC4TIPARPALDH1A1 | |
| SCHEMBL20818433 | 0.71 | TRPC5 (0.50) | TRPC5KCNH2TRPC4MKNK1MKNK2 | |
| SCHEMBL20818378 | 0.71 | TRPC5 (0.64) | TRPC5KCNH2TRPC4AKR1B1TIPARP | |
| SCHEMBL20818043 | 0.71 | TRPC5 (1.00) | TRPC5KCNH2TRPC4ALDH1A1 | |
| SCHEMBL20831710 | 0.71 | TRPC5 (0.61) | TRPC5KCNH2TRPC4TIPARPALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8258134-B2 | Pyridazinone glucokinase activators | HOFFMANN-LA ROCHE INC. (US) | 2012-09-04 | — | — | US | disclosed |
| CN-102007116-A | Pyridazinone glucokinase activators | HOFFMANN LA ROCHE | 2011-04-06 | — | — | CN | disclosed |
| EP-2268633-A1 | PYRIDAZINONE GLUCOKINASE ACTIVATORS | F. Hoffmann-La Roche AG (CH) | 2011-01-05 | — | — | EP | disclosed |
| US-20090264434-A1 | PYRIDAZINONE GLUCOKINASE ACTIVATORS | BERTHEL STEVEN JOSEPH | 2009-10-22 | — | — | US | disclosed |
| WO-2009127544-A1 | PYRIDAZINONE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-10-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264434-A1 | PYRIDAZINONE GLUCOKINASE ACTIVATORS | GCK, GCKR, PDXK | TRPC5 3891/4885KCNH2 1074/4885TRPC4 3985/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.