Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.41 |
| ▸ | SYK | P43405 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 7/20 | 0.35 |
| ▸ | PDE6A | P16499 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.35 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10094164 | 0.91 | PDE5A (0.37) | PIK3CASYKBRD4ATAD2PDE5A | |
| SCHEMBL10094285 | 0.88 | PIK3CA (0.40) | PIK3CASYKBRD4ATAD2MTOR | |
| SCHEMBL10094286 | 0.86 | SYK (0.36) | SYKBRD4ATAD2PDE5APDE6A | |
| SCHEMBL10094179 | 0.83 | PTPN11 (0.35) | PIK3CABRD4ATAD2MTORMAPK6 | |
| SCHEMBL13492744 | 0.82 | ACACB (0.36) | PIK3CAMTORMAPK6CRHR1 | |
| SCHEMBL10094172 | 0.80 | MERTK (0.42) | PIK3CASYKBRD4ATAD2KCNH2 | |
| SCHEMBL12057668 | 0.77 | CRHR1 (0.32) | PIK3CACRHR1 | |
| SCHEMBL10094205 | 0.76 | CRHR1 (0.37) | PIK3CACRHR1 | |
| SCHEMBL10094144 | 0.75 | IRAK4 (0.37) | SYKBRD4ATAD2MTORPDE4D | |
| SCHEMBL10094115 | 0.75 | SYK (0.40) | PIK3CASYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120107271-A1 | ETHYNYL-SUBSTITUTED PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATING VIRAL INFECTIONS | MERCK SHARP & DOHME LLC | 2012-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120107271-A1 | ETHYNYL-SUBSTITUTED PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATING VIRAL INFECTIONS | CYP2C9, P2RX3, F12 | PIK3CA 2041/4885SYK 2450/4885BRD4 1726/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.