Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 2/20 | 0.50 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.49 |
| ▸ | ERN1 | O75460 | 5/20 | 0.47 |
| ▸ | BRD4 | O60885 | 2/20 | 0.46 |
| ▸ | CECR2 | Q9BXF3 | 3/20 | 0.45 |
| ▸ | BRD9 | Q9H8M2 | 3/20 | 0.45 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.45 |
| ▸ | TAF1 | P21675 | 1/20 | 0.45 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.45 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.45 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.45 |
| ▸ | EP300 | Q09472 | 1/20 | 0.45 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.45 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.45 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10094443 | 0.83 | KCNA5 (0.51) | KCNA5PDK2ERN1BRD4CECR2 | |
| SCHEMBL26356060 | 0.83 | AKR1C3 (0.47) | BRD4CREBBPBAZ2BBAZ2AKMT2A | |
| SCHEMBL10094322 | 0.83 | KMO (0.56) | KMT2AFFAR1LMNA | |
| SCHEMBL10094392 | 0.82 | KDM4E (0.50) | KCNA5KMT2AFFAR1 | |
| SCHEMBL4068672 | 0.82 | BAZ2B (0.51) | PDK2BRD4CREBBPBAZ2BBAZ2A | |
| SCHEMBL10094391 | 0.81 | KCNA5 (0.41) | KCNA5KMT2AMEN1FFAR1LMNA | |
| SCHEMBL23479668 | 0.79 | PDK2 (0.49) | PDK2BRD4TAF1CREBBPKMT2A | |
| SCHEMBL23479756 | 0.79 | RAB9A (0.49) | PDK2ERN1SMN1; SMN2FFAR1 | |
| SCHEMBL15723874 | 0.79 | KCNA5 (0.53) | KCNA5PDK2ERN1BRD4CECR2 | |
| SCHEMBL10094496 | 0.78 | KCNA5 (0.52) | KCNA5ERN1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148535-B2 | Potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2012-04-03 | — | — | US | disclosed |
| US-20090233897-A1 | Potassium Channel Inhibitors | MERCK SHARP & DOHME CORP. | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233897-A1 | Potassium Channel Inhibitors | KCNJ2, KCNQ2, KCNH2 | KCNA5 11/4885PDK2 1535/4885ERN1 1811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.