Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.62 |
| ▸ | NT5E | P21589 | 1/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | TYK2 | P29597 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | STAT3 | P40763 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.50 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10094389 | 0.87 | SIRT2 (0.65) | SIRT2KDM4ENPC1RAB9ALMNA | |
| SCHEMBL10094383 | 0.82 | NPC1 (0.59) | KDM4ENPC1RAB9ALMNAHTT | |
| SCHEMBL10094388 | 0.82 | SIRT2 (0.63) | SIRT2KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL23479668 | 0.80 | PDK2 (0.49) | JAK2LMNAKCNK3KCNK9NR1H4 | |
| SCHEMBL12057348 | 0.78 | NT5E (0.67) | SIRT2NT5EROCK2JAK2TYK2 | |
| SCHEMBL2445126 | 0.78 | ROCK2 (0.69) | SIRT2NT5EROCK2POLBSTAT3 | |
| SCHEMBL10094392 | 0.77 | KDM4E (0.50) | KDM4EHTTALDH1A1PDE4B | |
| SCHEMBL14246056 | 0.76 | ROCK2 (0.70) | ROCK2 | |
| SCHEMBL10094322 | 0.76 | KMO (0.56) | LMNANR1H4 | |
| SCHEMBL26356060 | 0.76 | AKR1C3 (0.47) | LMNAKCNK3KCNK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148535-B2 | Potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2012-04-03 | — | — | US | disclosed |
| US-20090233897-A1 | Potassium Channel Inhibitors | MERCK SHARP & DOHME CORP. | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233897-A1 | Potassium Channel Inhibitors | KCNJ2, KCNQ2, KCNH2 | SIRT2 722/4885NT5E 1634/4885ROCK2 1928/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.