Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFRA2 | O00451 | 1/20 | 0.39 |
| ▸ | GFRA3 | O60609 | 1/20 | 0.39 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | CCR8 | P51685 | 2/20 | 0.36 |
| ▸ | CTSD | P07339 | 4/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.34 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1011187 | 0.88 | SMYD3 (0.40) | GFRA2GFRA3SLC7A5POLB | |
| SCHEMBL1944769 | 0.88 | SMYD3 (0.40) | GFRA2GFRA3SLC7A5POLB | |
| SCHEMBL1943686 | 0.88 | SMYD3 (0.40) | GFRA2GFRA3SLC7A5POLB | |
| SCHEMBL1083605 | 0.79 | KDM4E (0.44) | GFRA2GFRA3HCRTR1HCRTR2CTSD | |
| SCHEMBL1083604 | 0.79 | KDM4E (0.44) | GFRA2GFRA3HCRTR1HCRTR2CTSD | |
| SCHEMBL24373809 | 0.77 | SLC7A5 (0.42) | SLC7A5HDAC8POLBPTGDR2 | |
| SCHEMBL1943183 | 0.74 | P2RX3 (0.42) | GFRA2GFRA3PTGDR2P2RX3P2RX2 | |
| SCHEMBL1943185 | 0.74 | P2RX3 (0.42) | GFRA2GFRA3PTGDR2P2RX3P2RX2 | |
| SCHEMBL1942311 | 0.72 | SMYD3 (0.40) | SLC7A5POLB | |
| SCHEMBL1644213 | 0.71 | MMP9 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268611-A2 | AMINOALKYLPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | Amira Pharmaceuticals, Inc. (US) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009145989-A2 | AMINOALKYLPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2009-12-03 | — | — | WO | disclosed |