Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 9/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | CASP3 | P42574 | 2/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | CASP2 | P42575 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 2/20 | 0.47 |
| ▸ | PLG | P00747 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.46 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.46 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30983347 | 0.94 | FOLH1 (0.60) | FOLH1TDP1CASP3CASP1CASP2 | |
| SCHEMBL19514702 | 0.94 | FOLH1 (0.60) | FOLH1TDP1CASP3CASP1CASP2 | |
| SCHEMBL30341710 | 0.94 | FOLH1 (0.60) | FOLH1TDP1CASP3CASP1CASP2 | |
| SCHEMBL30918604 | 0.94 | FOLH1 (0.60) | FOLH1TDP1CASP3CASP1CASP2 | |
| SCHEMBL9169411 | 0.94 | FOLH1 (0.60) | FOLH1TDP1CASP3CASP1CASP2 | |
| SCHEMBL31003995 | 0.94 | FOLH1 (0.60) | FOLH1TDP1CASP3CASP1CASP2 | |
| SCHEMBL12372459 | 0.94 | FOLH1 (0.60) | FOLH1TDP1CASP3CASP1CASP2 | |
| SCHEMBL9175340 | 0.93 | FOLH1 (0.59) | FOLH1TDP1CASP3CASP1CASP2 | |
| SCHEMBL31004008 | 0.89 | FOLH1 (0.69) | FOLH1TDP1CASP3CASP1CASP2 | |
| SCHEMBL30302185 | 0.89 | FOLH1 (0.69) | FOLH1TDP1CASP3CASP1CASP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11285165-B2 | Selective high-affinity polydentate ligands and methods of making such | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (US) | 2022-03-29 | — | — | US | disclosed |
| US-20210106677-A1 | VACCINE DEVELOPMENT METHODOLOGY BASED ON AN ADHESION MOLECULE | MATSFIDE, INC. (US) | 2021-04-15 | — | — | US | disclosed |
| US-20210000843-A1 | SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (US) | 2021-01-07 | — | — | US | disclosed |
| US-10874678-B2 | Selective high-affinity polydentate ligands and methods of making such | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (US) | 2020-12-29 | — | — | US | disclosed |
| US-10646502-B2 | Selective high-affinity polydentate ligands and methods of making such | LAWRENCE LIVERMORE NATIONAL SECURITY (US) | 2020-05-12 | — | — | US | disclosed |
| US-20190262364-A1 | SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (US) | 2019-08-29 | — | — | US | disclosed |
| US-10292992-B2 | Selective high-affinity polydentate ligands and methods of making such | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (US) | 2019-05-21 | — | — | US | disclosed |
| US-9884070-B2 | Selective high-affinity polydentate ligands and methods of making such | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (US) | 2018-02-06 | — | — | US | disclosed |
| US-20180008621-A1 | SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (US) | 2018-01-11 | — | — | US | disclosed |
| US-20180008622-A1 | SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (US) | 2018-01-11 | — | — | US | disclosed |
| EP-2268654-B1 | SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH | UNIV CALIFORNIA (US) | 2017-01-25 | — | — | EP | disclosed |
| US-8536133-B2 | Selective high-affinity polydentate ligands and methods of making such | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC. (US) | 2013-09-17 | — | — | US | disclosed |
| US-20110144065-A1 | SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH | U.S. DEPARTMENT OF ENERGY | 2011-06-16 | — | — | US | disclosed |
| EP-2268654-A2 | SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH | The Regents of the University of California (US) | 2011-01-05 | — | — | EP | disclosed |
| US-20100184702-A1 | Selective High-Affinity Polydentate Ligands and Methods of Making Such | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC | 2010-07-22 | — | — | US | disclosed |
| US-7662785-B2 | Selective high affinity polydentate ligands and methods of making such | THE REGENTS OF CALIFORNIA (US) | 2010-02-16 | — | — | US | disclosed |
| WO-2009132020-A2 | SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-10-29 | — | — | WO | disclosed |
| US-20060084115-A1 | Selective high affinity polydentate ligands and methods of making such | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2006-04-20 | — | — | US | disclosed |
| WO-2005077065-A2 | SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2005-08-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10646502-B2 | Selective high-affinity polydentate ligands and methods of making such | CD44, FCGR3B, FCGR2A | FOLH1 952/4885TDP1 4449/4885CASP3 4820/4885 |
| US-11285165-B2 | Selective high-affinity polydentate ligands and methods of making such | CD44, FCGR3B, FCGR2A | FOLH1 952/4885TDP1 4449/4885CASP3 4820/4885 |
| US-20110144065-A1 | SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH | CD44, FCGR3B, FCGR2A | FOLH1 952/4885TDP1 4449/4885CASP3 4820/4885 |
| US-20100184702-A1 | Selective High-Affinity Polydentate Ligands and Methods of Making Such | CD44, FCGR3B, FCGR2A | FOLH1 952/4885TDP1 4449/4885CASP3 4820/4885 |
| US-20180008621-A1 | SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH | CD44, FCGR3B, FCGR2A | FOLH1 952/4885TDP1 4449/4885CASP3 4820/4885 |
| US-20180008622-A1 | SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH | CD44, FCGR3B, FCGR2A | FOLH1 952/4885TDP1 4449/4885CASP3 4820/4885 |
| US-20190262364-A1 | SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH | CD44, FCGR3B, FCGR2A | FOLH1 952/4885TDP1 4449/4885CASP3 4820/4885 |
| US-10874678-B2 | Selective high-affinity polydentate ligands and methods of making such | CD44, FCGR3B, FCGR2A | FOLH1 952/4885TDP1 4449/4885CASP3 4820/4885 |
| US-20210000843-A1 | SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH | CD44, FCGR3B, FCGR2A | FOLH1 952/4885TDP1 4449/4885CASP3 4820/4885 |
| US-10292992-B2 | Selective high-affinity polydentate ligands and methods of making such | CD44, FCGR3B, FCGR2A | FOLH1 952/4885TDP1 4449/4885CASP3 4820/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.