⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13460251 | 0.88 | — | — | |
| SCHEMBL17087014 | 0.80 | — | — | |
| SCHEMBL10099624 | 0.79 | — | — | |
| Desacylcynaropicrin SCHEMBL1712162 | 0.71 | MAPT (0.33) | — | |
| Desacylcynaropicrin SCHEMBL10307509 | 0.71 | MAPT (0.33) | — | |
| SCHEMBL19222395 | 0.64 | CYP19A1 (0.34) | — | |
| SCHEMBL22877988 | 0.64 | MAPK1 (0.41) | — | |
| SCHEMBL12459727 | 0.64 | MAPK1 (0.41) | — | |
| SCHEMBL10307521 | 0.62 | MAPK1 (0.41) | — | |
| Isozaluzanin C SCHEMBL24453721 | 0.61 | PKM (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170224698-A1 | USE OF PARTHENOLIDE DERIVATIVES AS ANTILEUKEMIC AND CYTOTOXIC AGENTS | UNIV OF KENTUCKY (US) | 2017-08-10 | — | — | US | disclosed |
| US-9447112-B2 | Use of parthenolide derivatives as antileukemic and cytotoxic agents | UNIVERSITY OF KENTUCKY (US) | 2016-09-20 | — | — | US | disclosed |
| US-20150259356-A1 | USE OF PARTHENOLIDE DERIVATIVES AS ANTILEUKEMIC AND CYTOTOXIC AGENTS | UNIV KENTUCKY (US) | 2015-09-17 | — | — | US | disclosed |
| US-9045490-B2 | Use of parthenolide derivatives as antileukemic and cytotoxic agents | UNIVERSITY OF KENTUCKY (US) | 2015-06-02 | — | — | US | disclosed |
| US-20150099731-A1 | USE OF PARTHENOLIDE DERIVATIVES AS ANTILEUKEMIC AND CYTOTOXIC AGENTS | UNIVERSITY OF KENTUCKY (US) | 2015-04-09 | — | — | US | disclosed |
| US-20130288371-A1 | USE OF PARTHENOLIDE DERIVATIVES AS ANTILEUKEMIC AND CYTOTOXIC AGENTS | UNIV KENTUCKY (US) | 2013-10-31 | — | — | US | disclosed |
| US-8470875-B2 | Use of parthenolide derivatives as antileukemic and cytotoxic agents | UNIVERSITY OF KENTUCKY (US) | 2013-06-25 | — | — | US | disclosed |
| US-8124652-B2 | Use of parthenolide derivatives as antileukemic and cytotoxic agents | UNIVERSITY OF KENTUCKY (US) | 2012-02-28 | — | — | US | disclosed |
| US-20100184745-A1 | USE OF PARTHENOLIDE DERIVATIVES AS ANTILEUKEMIC AND CYTOTOXIC AGENTS | UNIVERSITY OF KENTUCKY (US) | 2010-07-22 | — | — | US | disclosed |
| US-7678904-B2 | or to treat autoimmune and inflammatory disorders; improved water solubility characteristics | UNIVERSITY OF KENTUCKY (US) | 2010-03-16 | — | — | US | disclosed |
| US-7312242-B2 | Use of parthenolide derivatives as antileukemic and cytotoxic agents | UNIVERSITY OF KENTUCKY (US) | 2007-12-25 | — | — | US | disclosed |