Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10307516 | 0.80 | MAPK1 (0.40) | MAPK1LMNACYP1A2 | |
| SCHEMBL10307511 | 0.78 | MAPK1 (0.42) | MAPK1LMNACYP1A2 | |
| SCHEMBL10307521 | 0.77 | MAPK1 (0.41) | MAPK1LMNACYP1A2 | |
| SCHEMBL22877988 | 0.76 | MAPK1 (0.41) | MAPK1LMNACYP1A2 | |
| SCHEMBL10307518 | 0.74 | MAPT (0.32) | — | |
| Grossheimin SCHEMBL1711489 | 0.68 | MAPT (0.34) | MAPK1 | |
| Grossheimin SCHEMBL1711493 | 0.68 | MAPT (0.34) | MAPK1 | |
| SCHEMBL15449258 | 0.67 | MEN1 (0.31) | — | |
| SCHEMBL18180889 | 0.65 | MAPT (0.35) | MAPK1 | |
| SCHEMBL10307520 | 0.65 | MAPT (0.35) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200055835-A1 | USE OF TRICYCLIC SESQUITERPENE LACTONES IN THE TREATMENT OF OBESITY AND RELATED DISEASES AND NON-THERAPEUTIC TREATABLE CONDITIONS | NEEM BIOTECH LTD (GB) | 2020-02-20 | — | — | US | disclosed |
| EP-3260449-A1 | USE OF TRICYCLIC SESQUITERPENE LACTONES IN THE TREATMENT OF OBESITY AND RELATED DISEASES AND NON-THERAPEUTIC TREATABLE CONDITIONS | Neem Biotech Ltd. (GB) | 2017-12-27 | — | — | EP | disclosed |
| EP-2523946-B1 | Tricyclic sesquiterpene lactones for used in the treatment of obesity and related diseases and non-therapeutic treatable conditions | NEEM BIOTECH LTD (GB) | 2017-09-20 | — | — | EP | disclosed |
| US-20130023586-A1 | USE OF TRICYCLIC SESQUITERPENE LACTONES IN THE TREATMENT OF OBESITY AND RELATED DISEASES AND NON-THERAPEUTIC TREATABLE CONDITIONS | INTERMED DISCOVERY GMBH (DE) | 2013-01-24 | — | — | US | disclosed |
| US-20130023586-A1 | USE OF TRICYCLIC SESQUITERPENE LACTONES IN THE TREATMENT OF OBESITY AND RELATED DISEASES AND NON-THERAPEUTIC TREATABLE CONDITIONS | INTERMED DISCOVERY GMBH (DE) | 2013-01-24 | — | — | US | disclosed |
| WO-2011085979-A1 | USE OF TRICYCLIC SESQUITERPENE LACTONES IN THE TREATMENT OF OBESITY AND RELATED DISEASES AND NON-THERAPEUTIC TREATABLE CONDITIONS | INTERMED DISCOVERY GMBH (DE) | 2011-07-21 | — | — | WO | disclosed |
| EP-2345646-A1 | Use of tricyclic sesquiterpene lactones in the treatment of obesity and related diseases and non-therapeutic treatable conditions | InterMed Discovery GmbH (DE) | 2011-07-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200055835-A1 | USE OF TRICYCLIC SESQUITERPENE LACTONES IN THE TREATMENT OF OBESITY AND RELATED DISEASES AND NON-THERAPEUTIC TREATABLE CONDITIONS | CETP, LIPC, FABP4 | MAPK1 3003/4885LMNA 719/4885CYP1A2 741/4885 |
| US-20130023586-A1 | USE OF TRICYCLIC SESQUITERPENE LACTONES IN THE TREATMENT OF OBESITY AND RELATED DISEASES AND NON-THERAPEUTIC TREATABLE CONDITIONS | CETP, LIPC, FABP4 | MAPK1 3003/4885LMNA 719/4885CYP1A2 741/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.