Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | CASP1 | P29466 | 1/20 | 0.56 |
| ▸ | CASP7 | P55210 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3599686 | 0.80 | LMNA (0.68) | MAPTLMNANPSR1TDP1CASP1 | |
| SCHEMBL30897352 | 0.80 | LMNA (0.68) | MAPTLMNANPSR1TDP1CASP1 | |
| SCHEMBL5551592 | 0.78 | LMNA (0.62) | MAPTLMNANPSR1TDP1CASP1 | |
| SCHEMBL30897395 | 0.78 | LMNA (0.65) | MAPTLMNANPSR1TDP1CASP1 | |
| SCHEMBL6873842 | 0.78 | LMNA (0.65) | MAPTLMNANPSR1TDP1CASP1 | |
| Hydrochloric Acid SCHEMBL8011144 | 0.77 | LMNA (0.71) | MAPTLMNANPSR1TDP1CASP1 | |
| SCHEMBL21855769 | 0.77 | HSD17B10 (0.68) | MAPTLMNANPSR1TDP1CASP1 | |
| SCHEMBL6873837 | 0.77 | LMNA (0.64) | MAPTLMNANPSR1TDP1CASP1 | |
| SCHEMBL3059715 | 0.76 | MEN1 (0.64) | MAPTLMNATDP1HSD17B10L3MBTL1 | |
| SCHEMBL6529824 | 0.76 | LMNA (0.62) | MAPTLMNANPSR1TDP1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007006-A1 | TRIAZOLO- AND PYRAZOLOQUINAZOLINE DERIVATIVES AS PDE10A ENZYME INHIBITOR | H. LUNDBECK A/S (DK) | 2012-01-19 | — | — | WO | disclosed |