Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | PLK1 | P53350 | 1/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.51 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14564384 | 0.84 | NR4A2 (0.49) | MAPTSMN1; SMN2ALDH1A1HTTNEK1 | |
| SCHEMBL259469 | 0.84 | GAA (0.51) | SMN1; SMN2PDGFRBALDH1A1HSD17B10HPGD | |
| SCHEMBL10099715 | 0.83 | PDGFRB (0.48) | MAPTSMN1; SMN2PLK1ADORA3ADORA2B | |
| SCHEMBL14736279 | 0.83 | ADORA3 (0.48) | MAPTSMN1; SMN2PLK1ADORA3ADORA2B | |
| SCHEMBL2719914 | 0.79 | MAPT (0.49) | MAPTSMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL2720218 | 0.76 | MAPT (0.53) | MAPTSMN1; SMN2PDGFRBALDH1A1NPC1 | |
| SCHEMBL16481876 | 0.76 | PDGFRB (0.54) | MAPTSMN1; SMN2PLK1PDGFRBKIT | |
| SCHEMBL28289637 | 0.76 | PDGFRB (0.54) | MAPTSMN1; SMN2ADORA1ADORA2APDGFRB | |
| SCHEMBL2185988 | 0.75 | MAPT (0.54) | MAPTSMN1; SMN2ADORA3PDGFRBALDH1A1 | |
| SCHEMBL14564397 | 0.75 | SCN9A (0.52) | SMN1; SMN2ALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007006-A1 | TRIAZOLO- AND PYRAZOLOQUINAZOLINE DERIVATIVES AS PDE10A ENZYME INHIBITOR | H. LUNDBECK A/S (DK) | 2012-01-19 | — | — | WO | disclosed |