Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 8/20 | 0.52 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | SDHB | P21912 | 2/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14564398 | 0.85 | SCN9A (0.64) | SCN9APDK2SCN10ATRPA1TRPM8 | |
| SCHEMBL14564384 | 0.81 | NR4A2 (0.49) | AXLALDH1A1SMN1; SMN2 | |
| SCHEMBL7823276 | 0.79 | PDK2 (0.57) | SCN9APDK2SDHBNPC1RAB9A | |
| SCHEMBL5440401 | 0.79 | SCN9A (0.74) | SCN9ASCN10ACFTR | |
| SCHEMBL259469 | 0.79 | GAA (0.51) | TRPM8AXLKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL10099708 | 0.75 | MAPT (0.60) | NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL3343465 | 0.73 | NOTUM (0.50) | SCN9APDK2ALDH1A1SMN1; SMN2 | |
| SCHEMBL2317784 | 0.70 | ESR1 (0.48) | NPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL21609778 | 0.69 | NOTUM (0.57) | SCN9APDK2SDHBSMN1; SMN2 | |
| SCHEMBL5934523 | 0.69 | PDK2 (0.49) | PDK2SLC6A2SLC6A4SLC6A3CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070060584-A1 | Biaryl substituted thiazoles, oxazoles and imidazoles as sodium channel blockers | MERCK & CO., INC. | 2007-03-15 | — | — | US | disclosed |
| US-20070060584-A1 | Biaryl substituted thiazoles, oxazoles and imidazoles as sodium channel blockers | MERCK & CO., INC. | 2007-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060584-A1 | Biaryl substituted thiazoles, oxazoles and imidazoles as sodium channel blockers | TRPV1, TRPA1, TRPV3 | SCN9A 70/4885PDK2 1748/4885SDHB 1515/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.