SCHEMBL10100588

SCHEMBL10100588

O=C1c2ccc3c4c(ccc(c24)C(=O)N1N(c1ccccc1)c1ccccc1)C(=O)N(N(c1ccccc1)c1ccccc1)C3=O

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.55
HTT P42858 3/20 0.55
HSP90AA1 P07900 1/20 0.55
HPGD P15428 1/20 0.55
XBP1 P17861 1/20 0.55
ALOX12 P18054 1/20 0.55
RUNX1 Q01196 1/20 0.55
ATM Q13315 1/20 0.55
CBFB Q13951 1/20 0.55
KMT2A Q03164 4/20 0.38
USP2 O75604 3/20 0.38
MEN1 O00255 3/20 0.38
KDM4E B2RXH2 2/20 0.38
MAPT P10636 2/20 0.38
KEAP1 Q14145 1/20 0.38
NFE2L2 Q16236 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
TERT O14746 2/20 0.36
POLB P06746 3/20 0.36
RECQL P46063 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10100550 0.89 ALDH1A1 (0.46) ALDH1A1HTTHSP90AA1HPGDXBP1
SCHEMBL19555141 0.87 ALDH1A1 (0.59) ALDH1A1HTTHSP90AA1HPGDXBP1
SCHEMBL11948153 0.87 ALDH1A1 (0.43) ALDH1A1HTTHSP90AA1HPGDXBP1
SCHEMBL11948105 0.87 ALDH1A1 (0.50) ALDH1A1HTTHSP90AA1HPGDXBP1
SCHEMBL11948154 0.84 ALDH1A1 (0.43) ALDH1A1HTTHSP90AA1HPGDXBP1
SCHEMBL11948106 0.84 ALDH1A1 (0.41) ALDH1A1HTTHSP90AA1HPGDXBP1
SCHEMBL11948107 0.83 ALDH1A1 (0.40) ALDH1A1HTTHSP90AA1HPGDXBP1
SCHEMBL11948112 0.82 POLB (0.60) ALDH1A1HTTHSP90AA1HPGDXBP1
SCHEMBL16864813 0.81 NTRK1 (0.44) ALDH1A1HTTHSP90AA1HPGDXBP1
SCHEMBL11948157 0.81 KEAP1 (0.55) ALDH1A1HTTHSP90AA1HPGDXBP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8380109-B2 Image forming apparatus and process cartridge RICOH COMPANY, LTD. (JP) 2013-02-19 US disclosed
US-8380109-B2 Image forming apparatus and process cartridge RICOH COMPANY, LTD. (JP) 2013-02-19 US disclosed
US-8110326-B2 Electrophotographic photoreceptor, image forming apparatus, and process cartridge RICOH COMPANY LIMITED (JP) 2012-02-07 US disclosed
US-8110326-B2 Electrophotographic photoreceptor, image forming apparatus, and process cartridge RICOH COMPANY LIMITED (JP) 2012-02-07 US disclosed
US-20090180804-A1 Image forming apparatus and process cartridge RICOH COMPANY, LTD. 2009-07-16 US disclosed
US-20090180804-A1 Image forming apparatus and process cartridge RICOH COMPANY, LTD. 2009-07-16 US disclosed
US-20080298840-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE RICOH COMPANY LIMITED (JP) 2008-12-04 US disclosed
US-20080298840-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE RICOH COMPANY LIMITED (JP) 2008-12-04 US disclosed