Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | PRNP | P04156 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CBFB | Q13951 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22949450 | 0.85 | KDM4E (0.37) | SMN1; SMN2KDM4ENPC1ALOX15RAB9A | |
| SCHEMBL15113128 | 0.81 | NPC1 (0.42) | SMN1; SMN2KDM4ENPC1ALOX15RAB9A | |
| SCHEMBL15113129 | 0.80 | NPC1 (0.41) | SMN1; SMN2KDM4ENPC1ALOX15RAB9A | |
| SCHEMBL14602877 | 0.77 | SMN1; SMN2 (0.35) | SMN1; SMN2KDM4ENPC1ALOX15RAB9A | |
| SCHEMBL25583481 | 0.76 | ATM (0.34) | ATMTDP1 | |
| SCHEMBL1102258 | 0.76 | SMN1; SMN2 (0.59) | SMN1; SMN2KDM4ENPC1ALOX15RAB9A | |
| SCHEMBL1102006 | 0.75 | SMN1; SMN2 (0.58) | SMN1; SMN2KDM4ENPC1ALOX15RAB9A | |
| SCHEMBL19367714 | 0.74 | KDM4E (0.39) | SMN1; SMN2KDM4ENPC1ALOX15RAB9A | |
| SCHEMBL14602872 | 0.74 | NPC1 (0.36) | SMN1; SMN2KDM4ENPC1ALOX15PRNP | |
| SCHEMBL10100735 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230374024-A1 | Compounds for the Treatment of Kinase-Dependent Disorders | EXELIXIS, INC. | 2023-11-23 | — | — | US | disclosed |
| US-11708367-B2 | Compounds for the treatment of kinase-dependent disorders | EXELIXIS, INC. (US) | 2023-07-25 | — | — | US | disclosed |
| US-11708367-B2 | Compounds for the treatment of kinase-dependent disorders | EXELIXIS, INC. (US) | 2023-07-25 | — | — | US | disclosed |
| US-11673897-B2 | Compounds for the treatment of kinase-dependent disorders | EXELIXIS, INC. (US) | 2023-06-13 | — | — | US | disclosed |
| US-11673897-B2 | Compounds for the treatment of kinase-dependent disorders | EXELIXIS, INC. (US) | 2023-06-13 | — | — | US | disclosed |
| US-20210040099-A1 | Compounds for the Treatment of Kinase-Dependent Disorders | EXELIXIS, INC. | 2021-02-11 | — | — | US | disclosed |
| US-20210032263-A1 | Compounds for the Treatment of Kinase-Dependent Disorders | EXELIXIS, INC. | 2021-02-04 | — | — | US | disclosed |
| US-20120041194-A1 | NITROGEN AND SULFUR-CONTAINING HETROCYCLE DERIVATIVES | TRIAD MULTITECH PHARMACEUTICALS, INC. (US) | 2012-02-16 | — | — | US | disclosed |
| US-20110269953-A1 | Nitrogen and Sulfur-Containing Heterocycle Derivatives | ARMILLI MURTY N | 2011-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11708367-B2 | Compounds for the treatment of kinase-dependent disorders | ERBB2, ERBB3, MAP3K6 | SMN1; SMN2 1215/4885KDM4E 2929/4885NPC1 1333/4885 |
| US-20210040099-A1 | Compounds for the Treatment of Kinase-Dependent Disorders | ERBB2, ERBB3, MAP3K6 | SMN1; SMN2 1215/4885KDM4E 2929/4885NPC1 1333/4885 |
| US-20230374024-A1 | Compounds for the Treatment of Kinase-Dependent Disorders | ERBB2, ERBB3, MAP3K6 | SMN1; SMN2 1215/4885KDM4E 2929/4885NPC1 1333/4885 |
| US-20120041194-A1 | NITROGEN AND SULFUR-CONTAINING HETROCYCLE DERIVATIVES | HRH4, HNMT, TST | SMN1; SMN2 1906/4885KDM4E 3862/4885NPC1 2247/4885 |
| US-20210032263-A1 | Compounds for the Treatment of Kinase-Dependent Disorders | ERBB2, MAP3K6, PRKCH | SMN1; SMN2 1437/4885KDM4E 2792/4885NPC1 1380/4885 |
| US-20110269953-A1 | Nitrogen and Sulfur-Containing Heterocycle Derivatives | TST, HNMT, HRH4 | SMN1; SMN2 1388/4885KDM4E 3542/4885NPC1 2114/4885 |
| US-11673897-B2 | Compounds for the treatment of kinase-dependent disorders | ERBB2, MAP3K6, PRKCH | SMN1; SMN2 1437/4885KDM4E 2792/4885NPC1 1380/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.