Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENTPD5 | O75356 | 2/20 | 0.63 |
| ▸ | SOD1 | P00441 | 1/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.45 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.45 |
| ▸ | CETP | P11597 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12234033 | 1.00 | ENTPD5 (0.63) | ENTPD5SOD1PIK3CBPTPN1HIF1A | |
| SCHEMBL12234034 | 1.00 | ENTPD5 (0.63) | ENTPD5SOD1PIK3CBPTPN1HIF1A | |
| SCHEMBL12234042 | 1.00 | ENTPD5 (0.63) | ENTPD5SOD1PIK3CBPTPN1HIF1A | |
| SCHEMBL12234382 | 0.81 | PIK3CB (0.48) | ENTPD5PIK3CBCYP3A4ALDH1A1CYP2C9 | |
| SCHEMBL6282209 | 0.80 | SOD1 (0.66) | SOD1NR1H2NR1H3CYP3A4HSP90AA1 | |
| SCHEMBL23995462 | 0.80 | ENTPD5 (0.41) | ENTPD5SOD1PTPN1HIF1AEPAS1 | |
| SCHEMBL12234047 | 0.79 | PIK3CB (0.55) | ENTPD5PIK3CBPTPN1HIF1AEPAS1 | |
| SCHEMBL12234043 | 0.79 | PIK3CB (0.55) | ENTPD5PIK3CBPTPN1HIF1AEPAS1 | |
| SCHEMBL23995072 | 0.79 | PIK3CB (0.55) | ENTPD5PIK3CBPTPN1HIF1AEPAS1 | |
| SCHEMBL12234050 | 0.79 | PIK3CB (0.55) | ENTPD5PIK3CBPTPN1HIF1AEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110263539-A1 | SHIP 1 MODULATOR COMPOUNDS | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2011-10-27 | — | — | US | disclosed |
| US-20110263539-A1 | SHIP 1 MODULATOR COMPOUNDS | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2011-10-27 | — | — | US | disclosed |
| WO-2007147251-A1 | SHIP 1 MODULATOR COMPOUNDS | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2007-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263539-A1 | SHIP 1 MODULATOR COMPOUNDS | PPM1F, PPM1D, PPP1R1B | ENTPD5 470/4885SOD1 4246/4885PIK3CB 87/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.