Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.79 |
| ▸ | MEN1 | O00255 | 5/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.79 |
| ▸ | GAA | P10253 | 3/20 | 0.79 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.79 |
| ▸ | USP7 | Q93009 | 1/20 | 0.61 |
| ▸ | KIF11 | P52732 | 3/20 | 0.58 |
| ▸ | AR | P10275 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | GRK6 | P43250 | 1/20 | 0.53 |
| ▸ | CYBB | P04839 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10101375 | 1.00 | MAPT (0.79) | MAPTKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL15299944 | 0.87 | GRK6 (0.73) | MAPTKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL14511548 | 0.80 | MAPT (0.79) | MAPTKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL12723007 | 0.80 | MAPT (0.79) | MAPTKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL10101414 | 0.79 | USP7 (0.63) | MAPTKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL23949811 | 0.78 | MAPT (0.81) | MAPTKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL681674 | 0.78 | MAPT (0.81) | MAPTKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL10101416 | 0.78 | AR (0.67) | MAPTKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL13343726 | 0.77 | KIF11 (0.63) | MAPTKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL5524785 | 0.76 | CA12 (0.80) | MAPTKDM4EMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110583-B2 | treatment of tumors; 1,5-bis(4'-(N-hydroxyamidino)phenoxy)pentane; maintain cells in the G2/M cell cycle | MERCK PATENT GMBH (DE) | 2012-02-07 | — | — | US | disclosed |
| US-8110583-B2 | treatment of tumors; 1,5-bis(4'-(N-hydroxyamidino)phenoxy)pentane; maintain cells in the G2/M cell cycle | MERCK PATENT GMBH (DE) | 2012-02-07 | — | — | US | disclosed |
| US-20080221118-A1 | treatment of tumors; 1,5-bis(4'-(N-hydroxyamidino)phenoxy)pentane; maintain cells in the G2/M cell cycle | MERCK PATENT GMBH (DE) | 2008-09-11 | — | — | US | disclosed |
| US-20080221118-A1 | treatment of tumors; 1,5-bis(4'-(N-hydroxyamidino)phenoxy)pentane; maintain cells in the G2/M cell cycle | MERCK PATENT GMBH (DE) | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221118-A1 | treatment of tumors; 1,5-bis(4'-(N-hydroxyamidino)phenoxy)pentane; maintain cells in the G2/M cell cycle | CCNE1, CCNA1, CCNT1 | MAPT 4565/4885KDM4E 3047/4885MEN1 125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.