Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | ACVRL1 | P37023 | 12/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.31 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.31 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.31 |
| ▸ | GAPDH | P04406 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | STAT6 | P42226 | 1/20 | 0.31 |
| ▸ | PI4KA | P42356 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10101590 | 0.90 | PIK3CD (0.40) | DOT1LPIK3CDACVRL1PRMT5 | |
| SCHEMBL10101526 | 0.90 | PIK3CD (0.40) | DOT1LPIK3CDACVRL1PRMT5 | |
| SCHEMBL13519792 | 0.87 | DOT1L (0.46) | DOT1LPIK3CDACVRL1PRMT5EGFR | |
| SCHEMBL10101597 | 0.82 | ADK (0.45) | PIK3CDACVRL1 | |
| SCHEMBL14642635 | 0.81 | PIK3CD (0.42) | DOT1LPIK3CDACVRL1 | |
| SCHEMBL10101558 | 0.81 | ADK (0.35) | DOT1LPIK3CDACVRL1EGFRERBB2 | |
| SCHEMBL10101562 | 0.81 | ACVRL1 (0.40) | DOT1LACVRL1DPP4MEN1SLC28A1 | |
| SCHEMBL10101568 | 0.81 | PIK3CD (0.36) | DOT1LPIK3CDACVRL1DPP4MEN1 | |
| SCHEMBL10101575 | 0.81 | CSNK2A2 (0.34) | DOT1LACVRL1DPP4MEN1SLC28A1 | |
| SCHEMBL10101598 | 0.80 | ADK (0.44) | PIK3CDACVRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119607-B2 | Bicyclic nucleosides and nucleotides as therapeutic agents | BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) | 2012-02-21 | — | — | US | disclosed |
| US-20100035836-A1 | BICYCLIC NUCLEOSIDES AND NUCLEOTIDES AS THERAPEUTIC AGENTS | BIOTA SCIENTIFIC MANAGEMENT (AU) | 2010-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035836-A1 | BICYCLIC NUCLEOSIDES AND NUCLEOTIDES AS THERAPEUTIC AGENTS | NTPCR, PNP, DCTD | DOT1L 3212/4885PIK3CD 636/4885ACVRL1 4215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.