Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.78 |
| ▸ | LCK | P06239 | 2/20 | 0.77 |
| ▸ | FBP1 | P09467 | 2/20 | 0.73 |
| ▸ | FLT1 | P17948 | 2/20 | 0.73 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.73 |
| ▸ | KDR | P35968 | 7/20 | 0.72 |
| ▸ | AURKA | O14965 | 2/20 | 0.64 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.64 |
| ▸ | GAK | O14976 | 2/20 | 0.64 |
| ▸ | PLK4 | O00444 | 1/20 | 0.64 |
| ▸ | CIT | O14578 | 1/20 | 0.64 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.64 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.64 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.64 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.64 |
| ▸ | BUB1 | O43683 | 1/20 | 0.64 |
| ▸ | KDM1A | O60341 | 1/20 | 0.64 |
| ▸ | JAK2 | O60674 | 1/20 | 0.64 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.64 |
| ▸ | STK17B | O94768 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14551678 | 0.94 | FBP1 (0.77) | EGFRLCKFBP1FLT1FGFR1 | |
| SCHEMBL10106511 | 0.92 | EGFR (0.75) | EGFRLCKFBP1FLT1FGFR1 | |
| SCHEMBL10101851 | 0.90 | EGFR (0.71) | EGFRLCKFBP1FLT1FGFR1 | |
| SCHEMBL5482884 | 0.88 | EGFR (1.00) | EGFRLCKFBP1FLT1FGFR1 | |
| Hydrochloric Acid SCHEMBL5475745 | 0.87 | EGFR (1.00) | EGFRLCKFBP1FLT1FGFR1 | |
| SCHEMBL4471854 | 0.86 | KDR (0.69) | EGFRLCKFBP1FLT1FGFR1 | |
| SCHEMBL2099775 | 0.85 | EGFR (0.83) | EGFRLCKFBP1FLT1FGFR1 | |
| SCHEMBL12694351 | 0.85 | EGFR (0.67) | EGFRLCKFBP1FLT1FGFR1 | |
| SCHEMBL22367416 | 0.85 | FBP1 (1.00) | EGFRLCKFBP1FLT1FGFR1 | |
| SCHEMBL668572 | 0.84 | EGFR (0.81) | EGFRLCKFBP1FLT1FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120046461-A1 | STEROIDAL ANTI-HORMONE HYBRIDS | NORTHEASTERN UNIVERSITY (US) | 2012-02-23 | — | — | US | disclosed |
| US-20120046461-A1 | STEROIDAL ANTI-HORMONE HYBRIDS | NORTHEASTERN UNIVERSITY (US) | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046461-A1 | STEROIDAL ANTI-HORMONE HYBRIDS | ESRRA, ESRRB, NR5A1 | EGFR 768/4885LCK 4032/4885FBP1 3262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.