SCHEMBL10102840

SCHEMBL10102840

C=CC(=O)Oc1ccc(N(c2ccccc2)c2ccc(CCc3ccc(CCc4ccc(N(c5ccccc5)c5ccccc5)cc4)cc3)cc2)cc1

nearest known ligand 0.63

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
THRB P10828 4/20 0.63
PDE6D O43924 1/20 0.42
THRA P10827 1/20 0.41
FFAR1 O14842 4/20 0.40
PPARG P37231 3/20 0.39
PPARA Q07869 2/20 0.39
ATM Q13315 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
RAB9A P51151 3/20 0.39
NPC1 O15118 2/20 0.39
ALDH1A1 P00352 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
KMT2A Q03164 1/20 0.38
TSHR P16473 1/20 0.37
FFAR4 Q5NUL3 1/20 0.37
GAA P10253 1/20 0.37
TAAR1 Q96RJ0 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9915746 1.00 THRB (0.63) THRBPDE6DTHRAFFAR1PPARG
SCHEMBL13825129 0.96 THRB (0.58) THRBPDE6DTHRAFFAR1FFAR4
SCHEMBL9915747 0.95 THRB (0.57) THRBPDE6DTHRAFFAR1PPARG
SCHEMBL11987133 0.94 THRB (0.71) THRBPDE6DTHRAKMT2A
SCHEMBL12933812 0.93 THRB (0.59) THRBPDE6DTHRAFFAR1TDP1
SCHEMBL11938786 0.91 THRB (0.55) THRBPDE6DTHRAPPARGPPARA
SCHEMBL13777578 0.91 THRB (0.55) THRBPDE6DTHRAPPARGPPARA
SCHEMBL2602448 0.91 THRB (0.51) THRBPDE6DTHRAATMTDP1
SCHEMBL2609810 0.91 THRB (0.51) THRBPDE6DTHRAATMTDP1
SCHEMBL172549 0.91 THRB (0.51) THRBPDE6DTHRAATMTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8148038-B2 Image bearing member, process cartridge, image forming apparatus and method of forming image bearing member RICOH COMPANY, LTD. (JP) 2012-04-03 US disclosed
US-8148038-B2 Image bearing member, process cartridge, image forming apparatus and method of forming image bearing member RICOH COMPANY, LTD. (JP) 2012-04-03 US disclosed
US-20090148180-A1 IMAGE BEARING MEMBER, PROCESS CARTRIDGE, IMAGE FORMING APPARATUS AND METHOD OF FORMING IMAGE BEARING MEMBER RICOH COMPANY, LTD. (JP) 2009-06-11 US disclosed