Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC3 | Q13507 | 4/20 | 0.35 |
| ▸ | TRPC6 | Q9Y210 | 4/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 10/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 3/20 | 0.34 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.34 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.34 |
| ▸ | HTR3B | O95264 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.34 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10103196 | 0.90 | HSD11B1 (0.40) | TRPC3TRPC6HSD11B1TRPA1CACNA1C | |
| SCHEMBL10102950 | 0.90 | KDM1A (0.46) | TRPC3TRPC6HSD11B1TRPA1CACNA1C | |
| SCHEMBL10102943 | 0.90 | MAPK1 (0.39) | HSD11B1 | |
| SCHEMBL10103115 | 0.90 | HSD11B1 (0.42) | TRPC3TRPC6HSD11B1TRPA1CACNA1C | |
| SCHEMBL10103117 | 0.86 | MAPT (0.36) | TRPC3TRPC6HSD11B1TRPA1CACNA1C | |
| SCHEMBL10103461 | 0.85 | HTT (0.36) | HSD11B1HTR3EHTR3BCHRNA7HTR3A | |
| SCHEMBL10103112 | 0.85 | HSD11B1 (0.42) | HSD11B1 | |
| SCHEMBL10085602 | 0.85 | HSD11B1 (0.48) | HSD11B1 | |
| SCHEMBL525422 | 0.85 | HSD11B1 (0.48) | HSD11B1 | |
| SCHEMBL10103350 | 0.81 | HSD11B1 (0.43) | HSD11B1HTR3EHTR3BCHRNA7HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012015715-A1 | SUBSTITUTED THIAZOL-2-YLAMINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS 11-BETA HSD1 MODULATORS | HIGH POINT PHARMACEUTICALS, LLC (US) | 2012-02-02 | — | — | WO | disclosed |