Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.38 |
| ▸ | VNN1 | O95497 | 4/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10103199 | 0.91 | HTR3E (0.42) | HSD11B1ALDH1A1CHRNA7HTR3EHTR3B | |
| SCHEMBL525706 | 0.87 | HSD11B1 (0.57) | HSD11B1CYP17A1CYP19A1P2RX7 | |
| SCHEMBL10085606 | 0.87 | HSD11B1 (0.57) | HSD11B1CYP17A1CYP19A1P2RX7 | |
| SCHEMBL10102943 | 0.86 | MAPK1 (0.39) | HSD11B1ALDH1A1 | |
| SCHEMBL10103468 | 0.84 | HIF1A (0.40) | HSD11B1ALDH1A1CHRNA7HTR3EHTR3B | |
| SCHEMBL10103461 | 0.84 | HTT (0.36) | HSD11B1ALDH1A1CHRNA7HTR3EHTR3B | |
| SCHEMBL10103465 | 0.81 | TRPC3 (0.35) | HSD11B1CHRNA7HTR3EHTR3BHTR3A | |
| SCHEMBL10103445 | 0.80 | HSD11B1 (0.42) | HSD11B1ALDH1A1P2RX7CHRNA7HTR3E | |
| SCHEMBL10103346 | 0.80 | HSD11B1 (0.34) | HSD11B1CHRNA7HTR3EHTR3BHTR3A | |
| SCHEMBL525405 | 0.78 | HSD11B1 (0.55) | HSD11B1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012015715-A1 | SUBSTITUTED THIAZOL-2-YLAMINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS 11-BETA HSD1 MODULATORS | HIGH POINT PHARMACEUTICALS, LLC (US) | 2012-02-02 | — | — | WO | disclosed |