SCHEMBL10105233

SCHEMBL10105233

C=C1C=CN(C)c2ccccc21

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.38
RAB9A P51151 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
KDM4E B2RXH2 2/20 0.38
ALDH1A1 P00352 2/20 0.38
MAPT P10636 2/20 0.38
HTT P42858 2/20 0.38
MEN1 O00255 1/20 0.38
POLB P06746 1/20 0.38
BLM P54132 1/20 0.38
KMT2A Q03164 1/20 0.38
MCL1 Q07820 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
CES1 P23141 2/20 0.35
TTR P02766 1/20 0.35
GPR3 P46089 1/20 0.33
TP53 P04637 1/20 0.32
MAPK10 P53779 1/20 0.32
LMNA P02545 1/20 0.31
HPGD P15428 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20385007 0.86 NPC1 (0.33) NPC1RAB9ASMN1; SMN2KDM4EALDH1A1
SCHEMBL1822854 0.75 BRD4 (0.41) NPC1RAB9ASMN1; SMN2KDM4EALDH1A1
SCHEMBL16867577 0.75 NPC1 (0.36) NPC1RAB9ASMN1; SMN2KDM4EALDH1A1
SCHEMBL10086948 0.75 ALDH1A1 (0.41) NPC1RAB9ASMN1; SMN2KDM4EALDH1A1
SCHEMBL21370484 0.75 KDM4E (0.32) NPC1RAB9ASMN1; SMN2KDM4EALDH1A1
SCHEMBL13171882 0.72 MEN1 (0.52) NPC1RAB9ASMN1; SMN2KDM4EALDH1A1
SCHEMBL13061952 0.72 MAPT (0.49) NPC1RAB9ASMN1; SMN2KDM4EALDH1A1
SCHEMBL19265774 0.72
SCHEMBL13642931 0.72 MAPT (0.35) SMN1; SMN2MAPTHTTMEN1BLM
SCHEMBL10448839 0.71 MEN1 (0.54) NPC1RAB9ASMN1; SMN2KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2888572-B1 METHOD FOR COMPENSATING FOR THE AGING OF A REAGENT DURING FLUORESCENCE MEASUREMENTS CARRIED OUT ON PARTICLES, AND BIOLOGICAL ANALYSIS DEVICE IMPLEMENTING THE METHOD HORIBA ABX SAS / HORIBA LTD (FR) 2019-10-09 EP disclosed
EP-2722367-B1 INFRARED DYES FOR LASER MARKING AGFA GEVAERT (BE) 2018-03-28 EP disclosed
US-9881745-B2 Dye sensitized solar cell ADEKA CORPORATION (JP) 2018-01-30 US disclosed
CN-104641219-B Method for compensating for the aging of a reagent during the fluorescence measurement of particles, and bioanalytical device implementing the method 奥里巴ABX股份有限公司 2017-05-31 CN disclosed
US-9448175-B2 Method for compensating for the aging of a reagent during fluorescence measurements carried out on particles, and biological analysis device implementing the method HORIBA ABX SAS (FR) 2016-09-20 US disclosed
US-20160148758-A1 DYE SENSITIZED SOLAR CELL ADEKA CORPORATION (JP) 2016-05-26 US disclosed
US-9239408-B2 Colored photosensitive composition ADEKA CORPORATION (JP) 2016-01-19 US disclosed
US-20150241352-A1 Method for Compensating for the Aging of a Reagent During Fluorescence Measurements Carried out on Particles, and Biological Analysis Device Implementing the Method HORIBA ABX SAS (FR) 2015-08-27 US disclosed
US-9110350-B2 Color conversion filter ADEKA CORPORATION (JP) 2015-08-18 US disclosed
US-20150174132-A1 METHOD FOR TREATING B CELL REGULATED AUTOIMMUNE DISORDERS SYNTA PHARMACEUTICALS CORP (US) 2015-06-25 US disclosed
US-20130306920-A1 COLORED PHOTOSENSITIVE COMPOSITION ADEKA CORPORATION (JP) 2013-11-21 US disclosed
US-20130147345-A1 COLOR CONVERSION FILTER ADEKA CORPORATION (JP) 2013-06-13 US disclosed
EP-2010494-B1 SPECIFIC MONOCATIONIC MONOCHROMOPHORIC COMPOUNDS OF HYDRAZONE TYPE COMPRISING A 2-, 4-PYRIDINIUM OR 2-, 4-QUINOLINIUM UNIT, SYNTHESIS THEREOF, DYE COMPOSITIONS CONTAINING THEM, AND METHOD FOR DYEING KERATIN FIBRES OREAL (FR) 2012-02-01 EP disclosed
US-8012220-B2 Specific monocationic monochromophoric compounds of hydrazone type comprising a 2-, 4-pyridinium or 2-, 4-quinolinium unit, synthesis thereof, dye compositions containing them, and method for dyeing keratin fibres L'OREAL S.A. (FR) 2011-09-06 US disclosed
US-8012220-B2 Specific monocationic monochromophoric compounds of hydrazone type comprising a 2-, 4-pyridinium or 2-, 4-quinolinium unit, synthesis thereof, dye compositions containing them, and method for dyeing keratin fibres L'OREAL S.A. (FR) 2011-09-06 US disclosed
EP-1414393-B1 AGENT FOR COLORING KERATIN-CONTAINING FIBRES HENKEL AG & CO KGAA (DE) 2010-10-06 EP disclosed
US-20100178654-A1 REAGENT AND REAGENT KIT FOR ANALYSIS OF IMMATURE LEUKOCYTE SYSMEX CORPORATION (JP) 2010-07-15 US disclosed
US-20090300856-A1 SPECIFIC MONOCATIONIC MONOCHROMOPHORIC COMPOUNDS OF HYDRAZONE TYPE COMPRISING A 2-, 4-PYRIDINIUM OR 2-, 4-QUINOLINIUM UNIT, SYNTHESIS THEREOF, DYE COMPOSITIONS CONTAINING THEM, AND METHOD FOR DYEING KERATIN FIBRES L'OREAL S.A. (FR) 2009-12-10 US disclosed
US-20090300856-A1 SPECIFIC MONOCATIONIC MONOCHROMOPHORIC COMPOUNDS OF HYDRAZONE TYPE COMPRISING A 2-, 4-PYRIDINIUM OR 2-, 4-QUINOLINIUM UNIT, SYNTHESIS THEREOF, DYE COMPOSITIONS CONTAINING THEM, AND METHOD FOR DYEING KERATIN FIBRES L'OREAL S.A. (FR) 2009-12-10 US disclosed
WO-2007125238-A1 SPECIFIC MONOCATIONIC MONOCHROMOPHORIC COMPOUNDS OF HYDRAZONE TYPE COMPRISING A 2-, 4-PYRIDINIUM OR 2-, 4-QUINOLINIUM UNIT, SYNTHESIS THEREOF, DYE COMPOSITIONS CONTAINING THEM, AND METHOD FOR DYEING KERATIN FIBRES L'ORÉAL (FR) 2007-11-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090300856-A1 SPECIFIC MONOCATIONIC MONOCHROMOPHORIC COMPOUNDS OF HYDRAZONE TYPE COMPRISING A 2-, 4-PYRIDINIUM OR 2-, 4-QUINOLINIUM UNIT, SYNTHESIS THEREOF, DYE COMPOSITIONS CONTAINING THEM, AND METHOD FOR DYEING KERATIN FIBRES KRT18, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, H1-5 NPC1 4330/4885RAB9A 3671/4885SMN1; SMN2 4819/4885
US-20150174132-A1 METHOD FOR TREATING B CELL REGULATED AUTOIMMUNE DISORDERS REL, NFATC1, BCL6 NPC1 2090/4885RAB9A 830/4885SMN1; SMN2 4441/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.