Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 3/20 | 0.67 |
| ▸ | KDR | P35968 | 13/20 | 0.63 |
| ▸ | FLT1 | P17948 | 5/20 | 0.63 |
| ▸ | RAF1 | P04049 | 4/20 | 0.63 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.63 |
| ▸ | BRAF | P15056 | 3/20 | 0.63 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.63 |
| ▸ | RET | P07949 | 2/20 | 0.63 |
| ▸ | KIT | P10721 | 2/20 | 0.63 |
| ▸ | BCR | P11274 | 2/20 | 0.63 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.63 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.63 |
| ▸ | EPHA1 | P21709 | 2/20 | 0.63 |
| ▸ | TTK | P33981 | 2/20 | 0.63 |
| ▸ | FLT4 | P35916 | 2/20 | 0.63 |
| ▸ | FLT3 | P36888 | 2/20 | 0.63 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.63 |
| ▸ | CLK1 | P49759 | 2/20 | 0.63 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.63 |
| ▸ | CDK17 | Q00537 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14911164 | 0.92 | ABL1 (0.73) | ABL1KDRFLT1RAF1MAPK14 | |
| SCHEMBL19878613 | 0.91 | KDR (0.69) | ABL1KDRFLT1RAF1MAPK14 | |
| SCHEMBL19888733 | 0.91 | ABL1 (0.65) | ABL1KDRFLT1RAF1MAPK14 | |
| SCHEMBL1660178 | 0.90 | RAF1 (0.68) | ABL1KDRFLT1RAF1MAPK14 | |
| SCHEMBL1660412 | 0.89 | ABL1 (0.63) | ABL1KDRFLT1RAF1MAPK14 | |
| SCHEMBL19888749 | 0.89 | ABL1 (0.67) | ABL1KDRFLT1RAF1MAPK14 | |
| SCHEMBL1660403 | 0.87 | BRAF (0.68) | ABL1KDRFLT1RAF1MAPK14 | |
| SCHEMBL10105557 | 0.87 | KDR (0.68) | ABL1KDRFLT1RAF1MAPK14 | |
| SCHEMBL19888840 | 0.86 | KDR (0.66) | KDRFLT1MAPK14BRAF | |
| SCHEMBL10105558 | 0.86 | KDR (0.71) | ABL1KDRFLT1RAF1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3500257-B1 | KINASE INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF TREATING CANCER | ICAHN SCHOOL MED MOUNT SINAI (US) | 2025-07-02 | — | — | EP | disclosed |
| US-11066370-B2 | Kinase inhibitor compounds, compositions, and methods of treating cancer | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2021-07-20 | — | — | US | disclosed |
| US-11066370-B2 | Kinase inhibitor compounds, compositions, and methods of treating cancer | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2021-07-20 | — | — | US | disclosed |
| US-20200325103-A1 | KINASE INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF TREATING CANCER | ICAHN SCHOOL MED MOUNT SINAI (US) | 2020-10-15 | — | — | US | disclosed |
| US-20200325103-A1 | KINASE INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF TREATING CANCER | ICAHN SCHOOL MED MOUNT SINAI (US) | 2020-10-15 | — | — | US | disclosed |
| US-10519113-B2 | Kinase inhibitor compounds, compositions, and methods of treating cancer | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2019-12-31 | — | — | US | disclosed |
| US-10519113-B2 | Kinase inhibitor compounds, compositions, and methods of treating cancer | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2019-12-31 | — | — | US | disclosed |
| US-20190202789-A1 | KINASE INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF TREATING CANCER | ICHAN SCHOOL OF MEDICINE AT MOUNT SINAL (US) | 2019-07-04 | — | — | US | disclosed |
| US-20190202789-A1 | KINASE INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF TREATING CANCER | ICHAN SCHOOL OF MEDICINE AT MOUNT SINAL (US) | 2019-07-04 | — | — | US | disclosed |
| EP-3500257-A1 | KINASE INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF TREATING CANCER | Icahn School of Medicine at Mount Sinai (US) | 2019-06-26 | — | — | EP | disclosed |
| WO-2018035346-A1 | KINASE INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF TREATING CANCER | ICHAN SCHOOL OF MEDICINE AT MOUNT SINAL (US) | 2018-02-22 | — | — | WO | disclosed |
| WO-2018035346-A1 | KINASE INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF TREATING CANCER | ICHAN SCHOOL OF MEDICINE AT MOUNT SINAL (US) | 2018-02-22 | — | — | WO | disclosed |
| US-20120077851-A1 | Urea Derivatives as Kinase Inhibitors | MEDOLUTION LIMITED (US) | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200325103-A1 | KINASE INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF TREATING CANCER | MAP3K1, KSR1, MAP3K11 | ABL1 38/4885KDR 706/4885FLT1 660/4885 |
| US-10519113-B2 | Kinase inhibitor compounds, compositions, and methods of treating cancer | MAP3K1, KSR1, MAP3K11 | ABL1 38/4885KDR 706/4885FLT1 660/4885 |
| US-11066370-B2 | Kinase inhibitor compounds, compositions, and methods of treating cancer | MAP3K1, KSR1, MAP3K11 | ABL1 38/4885KDR 706/4885FLT1 660/4885 |
| US-20190202789-A1 | KINASE INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF TREATING CANCER | MAP3K1, KSR1, MAP3K11 | ABL1 38/4885KDR 706/4885FLT1 660/4885 |
| US-20120077851-A1 | Urea Derivatives as Kinase Inhibitors | MAP3K20, CDK20, MAP3K10 | ABL1 167/4885KDR 1768/4885FLT1 1247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.